Irafamdastat
Based on 1 Customer Validation
Irafamdastat (BMS-986368) is a covalently acting FAAH and MAGL inhibitor that penetrates the central nervous system. Irafamdastat is used in research on Alzheimer's disease, multiple sclerosis, and epilepsy.
For research use only. We do not sell to patients.
- Purity : 98.07%
- CAS No.: 2244136-58-9
- Formula: C20H21F3N4O4
- Molecular Weight:438.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Irafamdastatt may have benefits for diseases associated with neuronal hyperexcitability, such as agitation symptoms in Alzheimer's disease and spasticity symptoms in multiple sclerosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2244136-58-9
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Appearance Solid
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Molecular Weight 438.40
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Formula C20H21F3N4O4
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Color White to off-white
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SMILES
NC(C1=CC(OC(N2[C@@H](CN(CC2)CC3=CC(OC(F)(F)F)=CC=C3)C)=O)=CN=C1)=O
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Synonyms
BMS-986368; CC-97489; ABX-1772
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (228.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (11.41 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (11.41 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2810 mL | 11.4051 mL | 22.8102 mL | 57.0255 mL |
| 5 mM | 0.4562 mL | 2.2810 mL | 4.5620 mL | 11.4051 mL | |
| 10 mM | 0.2281 mL | 1.1405 mL | 2.2810 mL | 5.7026 mL | |
| 15 mM | 0.1521 mL | 0.7603 mL | 1.5207 mL | 3.8017 mL | |
| 20 mM | 0.1141 mL | 0.5703 mL | 1.1405 mL | 2.8513 mL | |
| 25 mM | 0.0912 mL | 0.4562 mL | 0.9124 mL | 2.2810 mL | |
| 30 mM | 0.0760 mL | 0.3802 mL | 0.7603 mL | 1.9009 mL | |
| 40 mM | 0.0570 mL | 0.2851 mL | 0.5703 mL | 1.4256 mL | |
| 50 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1405 mL | |
| 60 mM | 0.0380 mL | 0.1901 mL | 0.3802 mL | 0.9504 mL | |
| 80 mM | 0.0285 mL | 0.1426 mL | 0.2851 mL | 0.7128 mL | |
| 100 mM | 0.0228 mL | 0.1141 mL | 0.2281 mL | 0.5703 mL |
Irafamdastat Related Classifications
HY-177093 Related Classifications
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Keywords
- Irafamdastat
- 2244136-58-9
- BMS-986368
- CC-97489
- ABX-1772
- BMS986368
- BMS 986368
- CC97489
- CC 97489
- CC-97489
- ABX1772
- ABX 1772
- ABX-1772
- MAGL
- FAAH
- Monoacylglycerol lipase
- Fatty acid amide hydrolase
- Alzheimer's disease
- agitation
- anandamide
- blood-brain barrier
- central nervous system
- endocannabinoid
- epilepsy
- Inhibitor
- inhibitor
- inhibit