L-NIO
Based on 2 publication(s) in Google Scholar
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO induces a consistentfocal ischemic infarctin rats.
For research use only. We do not sell to patients.
- CAS No.: 36889-13-1
- Formula: C7H15N3O2
- Molecular Weight:173.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-NIO
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Biological Activity
Description
IC50 & Target
Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW | IC50 |
9 μM
Compound: L-NIO
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Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
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[PMID: 9873655] |
In Vitro
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 36889-13-1
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Molecular Weight 173.21
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Formula C7H15N3O2
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SMILES
CC(NCCC[C@@H](C(O)=O)N)=N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Mol Gastroenterol Hepatol
2021;11(3):683-696. PMID: 33075564 -
Eur J Pharmacol
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway. [Abstract]2026 Apr 24:178896. PMID: 42035941
Purity & Documentation
References
[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [Content Brief]
[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-NIO Related Classifications
HY-100986B Related Classifications
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