CD30
CD30, encoded by the TNFRSF8 gene, is a type I transmembrane receptor of the tumor necrosis factor receptor superfamily expressed transiently on activated T and B lymphocytes. Its defining feature is an elongated extracellular region of cysteine-rich repeats that binds CD30L (CD153), leading to TRAF-mediated NF-κB activation with context-dependent proliferative or apoptotic outcomes. CD30 is the hallmark of classical Hodgkin lymphoma and anaplastic large cell lymphoma and is otherwise nearly absent from resting tissues, a selectivity exploited by the antibody-drug conjugate brentuximab vedotin and by CD30-directed CAR T-cell constructs. Soluble CD30 serves as a disease-monitoring biomarker.
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CD30 Recombinant Proteins (11)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
