DMG-PEG2000-GRGDS

DMG-PEG2000-GRGDS is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. GRGDS peptide: Targeting/functional ligand-the GRGDS peptide contains the RGD sequence, which can specifically bind to integrins (especially αvβ3 and αvβ5) highly expressed on the surface of tumor vascular endothelial cells and various tumor cells, achieving tumor-targeted delivery.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.