1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. E1R

E1R 

Cat. No.: HY-116463 Purity: 99.28% ee.: 99.92%
Handling Instructions

E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.

For research use only. We do not sell to patients.

E1R Chemical Structure

E1R Chemical Structure

CAS No. : 1301211-78-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 307 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of E1R:

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Description

E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity[1].

In Vitro

The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells[1].

In Vivo

E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice[1].

Animal Model: Male ICR and Balb/c mice weighed 23-25 g[1]
Dosage: 0.1, 1 and 10 mg/kg
Administration: Administered i.p. 60 min before the training session
Result: Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.
Molecular Weight

232.28

Formula

C₁₃H₁₆N₂O₂

CAS No.

1301211-78-8

SMILES

O=C(CN1C(C[[email protected]@H]([[email protected]@H]1C)C2=CC=CC=C2)=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (258.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3051 mL 21.5257 mL 43.0515 mL
5 mM 0.8610 mL 4.3051 mL 8.6103 mL
10 mM 0.4305 mL 2.1526 mL 4.3051 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

E1RSigma ReceptorSig1RPAMcognitionmemorydisordersInhibitorinhibitorinhibit

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E1R
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