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Cat. No.: HY-163860

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EGFR-TK-IN-3

EGFR-TK-IN-3 (3) is an EGFR TK inhibitor, with an IC₅₀ of 2.33 μM against Erlotinib (HY-50896)-resistant A549 cells.

For research use only. We do not sell to patients.

Formula: C₃₈H₄₆FeN₆O₅
Molecular Weight:722.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

EGFR-TK-IN-3 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

EGFR-TK-IN-3 (3) is an EGFR TK inhibitor, with an IC₅₀ of 2.33 μM against Erlotinib (HY-50896)-resistant A549 cells^[1].

All EGFR Isoforms :

In Vitro

The compound’s mechanism of anticancer action involves acombination of EGFR TK inhibitory activity and the capability to generatereactive oxygen species in lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 722.65
Formula C₃₈H₄₆FeN₆O₅
SMILES

O=C(c1cccc1)CN2C=C(N=N2)C3=CC(NC4=NC=NC5=CC(OCCOC)=C(C=C54)OCCOC)=CC=C3.CC.CC.c6cccc6.[Fe]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Przemysław Biegański, et al. Organometallic–Erlotinib Conjugates Active against Lung Cancer Cells and as Emerging Virus Entry Inhibitors. Organometallics 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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