Cinnamaldehyde
Based on 3 publication(s) in Google Scholar
Cinnamaldehyde is a major and a bioactive compound isolated from the leaves of Cinnamomum osmophloeum kaneh. Cinnamaldehyde is a cytokine production inhibitor. Cinnamaldehyde has anti-bacteria, anti-oxidation, and anti-inflammatory properties.
For research use only. We do not sell to patients.
- Purity: ≥95.0%
- CAS No.: 104-55-2
- Formula: C9H8O
- Molecular Weight:132.16
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cinnamaldehyde
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
6.5 μM
Compound: 15
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Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels
Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels
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[PMID: 20356305] |
| CHO | EC50 |
61 μM
Compound: CA
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Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis
Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis
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[PMID: 30878828] |
| HCT-8 | IC50 |
15.6 μM
Compound: 12; CA
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Antiproliferative activity against human HCT8 cells after 72 hrs in presence of aspirin by MTT assay
Antiproliferative activity against human HCT8 cells after 72 hrs in presence of aspirin by MTT assay
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[PMID: 30037494] |
| HCT-8 | IC50 |
29.4 μM
Compound: 12; CA
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Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay
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[PMID: 30037494] |
| HEK293 | EC50 |
51.4 μM
Compound: CA 3
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Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count
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[PMID: 19945872] |
| HEK293 | EC50 |
9 μM
Compound: CA
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Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
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[PMID: 30878828] |
| RAW264.7 | IC50 |
43 μM
Compound: CA
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Inhibition of NF-kappaB transfected in LPS-stimulated mouse RAW264.7 cells
Inhibition of NF-kappaB transfected in LPS-stimulated mouse RAW264.7 cells
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[PMID: 18823786] |
Cinnamaldehyde inhibits ROS release and the activation of MAPKs as well as pro-inflammatory cytokines expression within TLRs activated cultured monocytes/macrophages[1]
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Cinnamaldehyde induces apoptosis by mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells, and induces apoptosis in human hepatoma cells through activation of the proapoptotic Bcl-2 family proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 104-55-2
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Appearance Liquid (Density: 1.05 g/cm3)
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Molecular Weight 132.16
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Formula C9H8O
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Color Colorless to yellow
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SMILES
O=CC=CC=1C=CC=CC1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure. [Abstract]2024 Jul 20:133:155894. PMID: 39089090 -
Biol Reprod
Aerobic exercises regulate the epididymal anion homeostasis of high-fat diet induced obese rats through TRPA1-mediated cl- and HCO3- secretion. [Abstract]2023 Jul 11;109(1):53-64. PMID: 37154585 -
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cinnamaldehyde Related Classifications
HY-N0609 Related Classifications
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