Curdlan
Based on 2 publication(s) in Google Scholar
Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases.
For research use only. We do not sell to patients.
- Purity : 98.01%
- CAS No.: 54724-00-4
- Formula: (C6H10O5)n
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Curdlan
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Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Flow Cytometry
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Flow Cytometry
Biological Activity
Description
IC50 & Target
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Dectin-1 |
In Vitro
Curdlan (10, 30, 100 μg/mL, 48 hours) activates dendritic cells by upregulating the expression of Dectin-1 and TLR4[2]. Curdlan (10, 30, 100 μg/mL, 24 hours) activates the immune effects of dendritic cells by regulating the cell cycle, enhancing dendritic cell migration ability, and increasing NO production[2]. Curdlan (50 μg/mL, 1 hour) induces tissue mast cells to modulate immune responses via the Dectin-1 receptor, stimulating their migration, synthesis of pro-inflammatory mediators, and production of ROS[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-induced mouse dendritic cells (BM cells from C57BL/6 mice)
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Concentration:10 μg/mL, 30 μg/mL, 100 μg/mL
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Incubation Time:48 hours
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Result:Increased the protein expression of Dectin-1 and TLR4.
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Cell Line:LPS-induced mouse dendritic cells (BM cells from C57BL/6 mice)
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Concentration:10 μg/mL, 30 μg/mL, 100 μg/mL
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Incubation Time:24 hours
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Result:Significantly enhanced the migration ability of dendritic cells.
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Cell Line:LPS-induced mouse dendritic cells (BM cells from C57BL/6 mice)
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Concentration:10 μg/mL, 30 μg/mL, 100 μg/mL
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Incubation Time:24 hours
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Result:Increased the proportion of dendritic cells in the G0/G1 phase.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16F10 melanoma model in C57BL/6 mice (B16F10 cells were implanted subcutaneously into syngeneic mice)[2]
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Dosage:10 mg/kg or 100 μg/mL
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Administration:Method 1: Intraperitoneal injection (i.p.), every two days for 14 days (accompanied by subcutaneous injection of dendritic cells once a day for 14 days) Method 2: Pre-treated dendritic cells with curdlan (100 μg/mL) in vitro for 48 hours, then injected the dendritic cells subcutaneously into mice once a day for a total of 14 days. Note: B dendritic cells were activated by 16F10 melanoma cell lysate.
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Result:Enhanced the antitumor immune response of dendritic cells.
Chemical Information
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CAS No. 54724-00-4
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Appearance Solid
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Formula (C6H10O5)n
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Color White to yellow
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SMILES
OC[C@H]1O[C@@H](C)[C@H](O)C(OC)[C@@H]1O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Curdlan/chitosan NIR-responsive in situ forming gel: An injectable scaffold for the treatment of epiphyseal plate injury. [Abstract]2025 May;308(Pt 1):142052. PMID: 40090650 -
Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.
Curdlan (3 mg; i.p.; once a week for twice) developed robust polyarthritis in BALB/c mice within four weeks.
Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.
Curdlan (3 mg; i.p.; once a week for twice) induced inflammation in BALB/c-ZAP70W163C mice.
Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.
Curdlan (3 mg; i.p.; once a week for twice) exacerbated inflammatory infiltrates and cartilage degradation in SKG mice.
Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.
Curdlan (3 mg; i.p.; once a week for twice) significantly increased the proportion of CD45+ immune cells in the joints of SKG mice.
Curdlan purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 28.
Curdlan (3 mg; i.p.; once a week for twice) significantly increased proportions of CD3+ T cells and CD11b+ myeloid cells in the soft tissues of SKG mouse ankle joints.
Purity & Documentation
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Data Sheet (288 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Masanori Miwa, et al. Food Applications of Curdlan. Food Hydrocolloids pp 119-124.
[2]. Kim HS, et al. Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling. Int Immunopharmacol. 2016 Oct;39:71-78. [Content Brief]
[3]. Żelechowska P, et al. Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor. Cell Immunol. 2020 May;351:104079. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Curdlan Related Classifications
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