NVS-ZP7-4
Based on 8 publication(s) in Google Scholar
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death.
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- Pureza: 98.85%
- No. CAS: 2349367-89-9
- Fòrmula: C28H28FN5OS
- Peso molecular:501.62
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Ferroptosis Compound Library
HY-L051
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Endoplasmic Reticulum Stress Compound Library
HY-L054
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Chemical Probe Library
HY-L063
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Heterocyclic Compound Library
HY-L138
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Cell Death Library
HY-L162
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) NVS-ZP7-4
More- Nat Commun. 2026 Feb 12;17(1):1214. [Abstract]
- J Adv Res. 2025 Feb 13:S2090-1232(25)00077-3. [Abstract]
- Cell Death Dis. 2021 Feb 19;12(2):198. [Abstract]
- Food Chem X. 2025 Sep 16:31:103046. [Abstract]
- Sci Total Environ. 2024 Nov 25:957:177679. [Abstract]
- Int J Mol Sci. 2023 Jul 20;24(14):11689. [Abstract]
- Sci Rep. 2023 Jul 21;13(1):11795. [Abstract]
- PLoS Genet. 2023 Sep 25;19(9):e1010950. [Abstract]
Actividad biológica
ZIP7[1].
NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2349367-89-9
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Appearance Solid
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Peso molecular 501.62
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Fòrmula C28H28FN5OS
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Color Light yellow to yellow
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SMILES
O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (8)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
J Adv Res
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function. [Abstract]2025 Feb 13:S2090-1232(25)00077-3. PMID: 39955018 -
Cell Death Dis
2021 Feb 19;12(2):198. PMID: 33608508 -
Food Chem X
Preparation, characterization, assembly, and stability of walnut peptide - zinc complexes and its ability to promote zinc transport in Caco-2 cells. [Abstract]2025 Sep 16:31:103046. PMID: 41036460 -
Sci Total Environ
ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure. [Abstract]2024 Nov 25:957:177679. PMID: 39579909 -
Int J Mol Sci
2023 Jul 20;24(14):11689. PMID: 37511448 -
Sci Rep
NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling. [Abstract]2023 Jul 21;13(1):11795. PMID: 37479837 -
PLoS Genet
2023 Sep 25;19(9):e1010950. PMID: 37747921
Solvente y solubilidad
DMSO : ≥ 125 mg/mL (249.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9935 mL | 9.9677 mL | 19.9354 mL | 49.8385 mL |
| 5 mM | 0.3987 mL | 1.9935 mL | 3.9871 mL | 9.9677 mL | |
| 10 mM | 0.1994 mL | 0.9968 mL | 1.9935 mL | 4.9839 mL | |
| 15 mM | 0.1329 mL | 0.6645 mL | 1.3290 mL | 3.3226 mL | |
| 20 mM | 0.0997 mL | 0.4984 mL | 0.9968 mL | 2.4919 mL | |
| 25 mM | 0.0797 mL | 0.3987 mL | 0.7974 mL | 1.9935 mL | |
| 30 mM | 0.0665 mL | 0.3323 mL | 0.6645 mL | 1.6613 mL | |
| 40 mM | 0.0498 mL | 0.2492 mL | 0.4984 mL | 1.2460 mL | |
| 50 mM | 0.0399 mL | 0.1994 mL | 0.3987 mL | 0.9968 mL | |
| 60 mM | 0.0332 mL | 0.1661 mL | 0.3323 mL | 0.8306 mL | |
| 80 mM | 0.0249 mL | 0.1246 mL | 0.2492 mL | 0.6230 mL | |
| 100 mM | 0.0199 mL | 0.0997 mL | 0.1994 mL | 0.4984 mL |
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