Andrimid
Andrimid is a peptide Antibiotic and acetyl-CoA carboxylase inhibitor. Andrimid is produced by symbiotic bacteria of the genus *Enterobacter* residing in the brown planthopper Nilaparvata lugens. Andrimid exhibits strong specific activity against Xanthomonas campestris pv. oryzae. Andrimid shows no or only weak activity against Gram-positive and Gram-negative bacteria, including most plant pathogenic bacteria. Andrimid can be used in studies related to bacterial infections and rice bacterial blight.
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- No. CAS: 108868-95-7
- Fòrmula: C27H33N3O5
- Peso molecular:479.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Andrimid (0.1 μg/mL) potently inhibits Xanthomonas campestris pv. oryzae strain NIAES 1225 with an MIC of 0.1 μg/mL and shows strong, specific activity against all tested Southeast Asian and Japanese X. campestris pv. oryzae strains, with significantly reduced activity against other bacterial pathovars and pathogens[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 108868-95-7
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Peso molecular 479.57
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Fòrmula C27H33N3O5
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SMILES
C/C=C/C=C/C=C/C(N[C@H](C1=CC=CC=C1)CC(N[C@@H](C(C)C)C([C@H]2[C@@H](C(NC2=O)=O)C)=O)=O)=O
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Structure Classification
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Initial Source
Erwinia persicina BST187
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Pureza y Documentación
Referencias
[1]. Matilla MA, et al. Biosynthesis of the acetyl-CoA carboxylase-inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR-type transcriptional regulator, AdmX. Environ Microbiol. 2016;18(11):3635-3650. [Content Brief]
[3]. Cheng T, et al. Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization. BMC Microbiol. 2023;23(1):268. Published 2023 Sep 25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Andrimid Related Classifications
HY-N14257 Related Classifications
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Keywords
- Andrimid
- 108868-95-7
- Bacterial
- Antibiotic
- Acetyl-CoA Carboxylase
- Enterobacter sp.
- Dickeya solani
- Bacillus subtilis
- Xanthomonas campestris pv. campestris
- Xanthomonas campestris pv. oryzae
- Serratia plymuthica A153
- Serratia marcescens MSU97
- acetyl-CoA carboxylase
- Nilaparvata lugens
- fatty acid biosynthesis
- Inhibitor
- inhibitor
- inhibit