Braftide
Based on 1 Customer Validation
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.51%
- No. CAS: 2411851-64-2
- Fòrmula: C57H94N16O13S
- Peso molecular:1243.52
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Kinase Inhibitor Library
HY-L009
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MAPK Compound Library
HY-L010
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HY-L025
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HY-L045
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Posttranslational Modification Library
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Actividad biológica
Chemical Information
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No. CAS 2411851-64-2
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Appearance Solid
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Peso molecular 1243.52
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Fòrmula C57H94N16O13S
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Color White to off-white
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Sequence
Thr-Arg-His-Val-Asn-Ile-Leu-Leu-Phe-Met
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Sequence Shortening
TRHVNILLFM
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (80.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8042 mL | 4.0208 mL | 8.0417 mL | 20.1042 mL |
| 5 mM | 0.1608 mL | 0.8042 mL | 1.6083 mL | 4.0208 mL | |
| 10 mM | 0.0804 mL | 0.4021 mL | 0.8042 mL | 2.0104 mL | |
| 15 mM | 0.0536 mL | 0.2681 mL | 0.5361 mL | 1.3403 mL | |
| 20 mM | 0.0402 mL | 0.2010 mL | 0.4021 mL | 1.0052 mL | |
| 25 mM | 0.0322 mL | 0.1608 mL | 0.3217 mL | 0.8042 mL | |
| 30 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6701 mL | |
| 40 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5026 mL | |
| 50 mM | 0.0161 mL | 0.0804 mL | 0.1608 mL | 0.4021 mL | |
| 60 mM | 0.0134 mL | 0.0670 mL | 0.1340 mL | 0.3351 mL | |
| 80 mM | 0.0101 mL | 0.0503 mL | 0.1005 mL | 0.2513 mL |
Braftide Related Classifications
HY-P10436 Related Classifications
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