SARS1 - seryl-tRNA synthetase 1 Gene

Also Known as SARS; SERS; SERRS; NEDMAS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6301

About SARS1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,213,893-109,238,182 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 44.0), brain (RPKM 25.3) and 25 other tissues.

Summary

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to Bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

SARS1 Products (2)

mRNA Protein Name
NM_001330669.1 NP_001317598.1 serine--tRNA ligase, cytoplasmic isoform b
NM_006513.4 NP_006504.2 serine--tRNA ligase, cytoplasmic isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24940000 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
28655767 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
34268557 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26433229 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
26433229 GOA
enables selenocysteine-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
34570399 GOA
enables serine-tRNA ligase activity IDA
IDA: Inferred from direct assay
24095058 GOA
enables serine-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
34570399 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in cytoplasmic translation IMP
IMP: Inferred from mutant phenotype
36041817 GOA
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
24940000 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24940000 GOA
involved in negative regulation of vascular endothelial growth factor production IDA
IDA: Inferred from direct assay
24940000 GOA
involved in selenocysteine incorporation IMP
IMP: Inferred from mutant phenotype
34570399 GOA
involved in seryl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
24095058 GOA
involved in seryl-tRNA aminoacylation IMP
IMP: Inferred from mutant phenotype
28236339 GOA
involved in tRNA modification IDA
IDA: Inferred from direct assay
34268557 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28236339 GOA
located in cytosol IDA
IDA: Inferred from direct assay
34570399 GOA
located in nucleus IDA
IDA: Inferred from direct assay
34570399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARS1 Protein Structure

Seryl_tRNA_N

Seryl_tRNA_N: Seryl-tRNA synthetase N-terminal domain (2 - 92)

tRNA-synt_2b

tRNA-synt_2b: tRNA synthetase class II core domain (G, H, P, S and T) (203 - 384)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

serine--tRNA ligase, cytoplasmic

  • serine tRNA ligase 1, cytoplasmic

SARS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
SARS1 P49591 SERTAD4 Homo sapiens Q9NUC0
Validated Y2H
32814053
Intra
SARS1 P49591 SERTAD4 Homo sapiens Q9NUC0
Y2H Pooling
32814053
Intra
SARS1 P49591 SERTAD4 Homo sapiens Q9NUC0
Y2H Array
32814053
Intra
SARS1 P49591 TMEM61 Homo sapiens Q8N0U2
Y2H Array
32814053
Intra
SARS1 P49591 TMEM61 Homo sapiens Q8N0U2
Y2H Pooling
32814053
Intra
SARS1 P49591 TMEM61 Homo sapiens Q8N0U2
Validated Y2H
32814053
Intra
SARS1 P49591 SWAP70 Homo sapiens Q9UH65
Y2H Pooling
32814053
Intra
SARS1 P49591 SWAP70 Homo sapiens Q9UH65
Validated Y2H
32814053
Intra
SARS1 P49591 SWAP70 Homo sapiens Q9UH65
Y2H Array
32814053
Intra
SARS1 P49591 SOCS6 Homo sapiens O14544
Y2H Pooling
32814053
Intra
SARS1 P49591 SOCS6 Homo sapiens O14544
Validated Y2H
32814053
Intra
SARS1 P49591 SOCS6 Homo sapiens O14544
Y2H Array
32814053
Intra
SARS1 P49591 RASSF1 Homo sapiens Q9NS23-4
Y2H Array
32814053
Intra
SARS1 P49591 RASSF1 Homo sapiens Q9NS23-4
Validated Y2H
32814053
Intra
SARS1 P49591 RASSF1 Homo sapiens Q9NS23-4
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures

  • NEDMAS
Arteriovenous Malformations Of The Brain

  • Cerebral Arteriovenous Malformation

  • Intracranial Arteriovenous Malformation

  • Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

  • Intracranial Arteriovenous Malformations

  • Bavm

  • Cerebral Arteriovenous Malformations

  • Intracranial Hemorrhage In Brain Cerebrovascular Malformations

  • Arteriovenous Malformation Of The Brain, Somatic

  • Intracranial Avm

  • Arteriovenous Malformations Cerebral
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Hyperuricemia

  • Blood Urate Raized

  • Uricacidemia
Joubert Syndrome 7

  • JBTS7

  • Cerebello-Oculo-Renal Syndrome 3

  • Cors3

  • Joubert Syndrome, Type 7
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Referencia número Nombre del producto Efecto
Pureza Rare Diseases
HY-P0205B Saralasin TFA Antagonist 99.37% Unkown
HY-P0205 Saralasin Antagonist 99.46% Unkown
HY-P1564A [Sar1, Ile8]-Angiotensin II TFA 99.85% Unkown
HY-P0205A Saralasin acetate hydrate Antagonist / Unkown
HY-P1564 [Sar1, Ile8]-Angiotensin II / Unkown

Pre-clinical Phase

Bioactive Molecules (12)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P4685 (Sar1,Ile4,8)-Angiotensin II Agonist 98.23% Unkown
HY-P3138 (Sar1)-Angiotensin II Agonist 99.84% Unkown
HY-RS12442 SAR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172265 FKBP12 PROTAC FM4 Degrader 99.95% Unkown
HY-P10640 [Sar1,Thr8]-Angiotensin II Antagonist / Unkown
HY-P11389 (Sar1,Gly8)-Angiotensin II Antagonist / Unkown
HY-RS12443 SAR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12448 SARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101823A A-81282 Antagonist / Unkown
HY-RS20487 Sar1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26995 Sar1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W140555 5,7-Dimethoxyphthalide Inhibitor 99.97% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SARS1 MGD MGI:102809
Bos taurus SARS1 VGNC VGNC:34291
Canis familiaris SARS1 VGNC VGNC:45869
Rattus norvegicus SARS1 RGD RGD:628813
Macaca mulatta SARS1 VGNC VGNC:100131
Others SARS1 NCBI