GX-201
Based on 1 Customer Validation
GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.46%
- No. CAS: 1788071-27-1
- Fòrmula: C25H27ClF4N2O4S
- Peso molecular:563.00
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Nav1.7 <3.2 nM (IC50) |
GX-201 produces analgesia at a free plasma concentration about 3 times the IC50[1].
GX-201 inhibits nociceptive responses induced by formalin and inflammatory pain caused by complete Freund’s adjuvant (CFA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-Type Mice[1].
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Dosage:0.3, 1, 3 mg/kg.
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Administration:Orally, once.
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Result:Produced a dose-dependent inhibition of the nociceptive events.
Chemical Information
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No. CAS 1788071-27-1
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Appearance Solid
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Peso molecular 563.00
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Fòrmula C25H27ClF4N2O4S
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Color White to off-white
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SMILES
O=C(C1=C(F)C=C(OCC2CCN(CC2)CC3=CC(C(F)(F)F)=CC=C3Cl)C(C4CC4)=C1)NS(=O)(C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 62.5 mg/mL (111.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7762 mL | 8.8810 mL | 17.7620 mL | 44.4050 mL |
| 5 mM | 0.3552 mL | 1.7762 mL | 3.5524 mL | 8.8810 mL | |
| 10 mM | 0.1776 mL | 0.8881 mL | 1.7762 mL | 4.4405 mL | |
| 15 mM | 0.1184 mL | 0.5921 mL | 1.1841 mL | 2.9603 mL | |
| 20 mM | 0.0888 mL | 0.4440 mL | 0.8881 mL | 2.2202 mL | |
| 25 mM | 0.0710 mL | 0.3552 mL | 0.7105 mL | 1.7762 mL | |
| 30 mM | 0.0592 mL | 0.2960 mL | 0.5921 mL | 1.4802 mL | |
| 40 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1101 mL | |
| 50 mM | 0.0355 mL | 0.1776 mL | 0.3552 mL | 0.8881 mL | |
| 60 mM | 0.0296 mL | 0.1480 mL | 0.2960 mL | 0.7401 mL | |
| 80 mM | 0.0222 mL | 0.1110 mL | 0.2220 mL | 0.5551 mL | |
| 100 mM | 0.0178 mL | 0.0888 mL | 0.1776 mL | 0.4440 mL |
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