HS-438
HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML).
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- No. CAS: 1430720-10-7
- Fòrmula: C17H17N3O3S
- Peso molecular:343.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
>10 μM
Compound: 10b
|
Cytotoxicity against mouse BA/F3 cells after 48 hrs by XTT assay
Cytotoxicity against mouse BA/F3 cells after 48 hrs by XTT assay
|
[PMID: 23600806] |
| BaF3 | IC50 |
0.089 μM
Compound: 10b
|
Cytotoxicity against mouse BA/F3 cells transfected with wild type Bcr-Abl after 48 hrs by XTT assay
Cytotoxicity against mouse BA/F3 cells transfected with wild type Bcr-Abl after 48 hrs by XTT assay
|
[PMID: 23600806] |
| BaF3 | IC50 |
0.14 μM
Compound: 10b
|
Cytotoxicity against mouse BA/F3 cells transfected with Bcr-Abl T315I mutant after 48 hrs by XTT assay
Cytotoxicity against mouse BA/F3 cells transfected with Bcr-Abl T315I mutant after 48 hrs by XTT assay
|
[PMID: 23600806] |
| K562 | IC50 |
0.12 μM
Compound: 10b
|
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
|
[PMID: 23600806] |
Chemical Information
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No. CAS 1430720-10-7
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Peso molecular 343.40
-
Fòrmula C17H17N3O3S
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SMILES
O=C(NCCO)NC1=NC2=CC=C(C=C2S1)C3=CC=CC=C3OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)