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Referencia número: HY-136393

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IKK-IN-4

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively.

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No. CAS: 615529-94-7
Fòrmula: C₁₈H₁₉N₅S
Peso molecular:337.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IKK-IN-4 Chemical Structure

No. CAS: 615529-94-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively^[1].

Ver todos los productos específicos de isoformas IKK :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	CC₅₀	21 μM Compound: 22f	Cytotoxicity against Jurkat cells by Alamar blue assay Cytotoxicity against Jurkat cells by Alamar blue assay	[PMID: 17540562]
Jurkat	EC₅₀	6.73 μM Compound: 22f	Inhibition of LPS-induced TNFalpha production in Jurkat cells Inhibition of LPS-induced TNFalpha production in Jurkat cells	[PMID: 17540562]

Chemical Information

No. CAS 615529-94-7
Peso molecular 337.44
Fòrmula C₁₈H₁₉N₅S
SMILES

CC1=CN=C2C(NC)=NC(C=C(C3=CC=CC(CCN)=C3)S4)=C4N21
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Belema M, et al. Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors. Bioorg Med Chem Lett. 2007;17(15):4284‐4289. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
Chemical Information
Pureza y Documentación
Referencias

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IKK-IN-4

Ver todos los productos específicos de isoformas IKK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

IKK-IN-4 Related Classifications

HY-136393 Related Classifications