SJ6986
Based on 1 publication(s) in Google Scholar
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.35%
- No. CAS: 2765625-93-0
- Fòrmula: C20H14F3N3O7S
- Peso molecular:497.40
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SJ6986
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Customer Validation & Images
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WB
Actividad biológica
DC50: 2.1 nM (GSPT1)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | EC50 |
1.5 nM
Compound: 6; SJ6986
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Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 3 days by CellTiter-Glo assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 3 days by CellTiter-Glo assay
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[PMID: 34042448] |
SJ6986 exhibits EC50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 cells.
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Concentration:0-100 μM.
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Incubation Time:3 days.
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Result:Exhibited EC50 of 1.5 nM.
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Cell Line:MV4-11 cells.
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Concentration:0-10 μM.
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Incubation Time:4 and 24 h.
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Result:Dose- and time-dependently decreased the protein levels of GSPT1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2765625-93-0
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Appearance Solid
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Peso molecular 497.40
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Fòrmula C20H14F3N3O7S
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Color White to yellow
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SMILES
O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Leukemia
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization. [Abstract]2025 Sep;39(9):2163-2173. PMID: 40670672
SJ6986 purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Sep;39(9):2163-2173. [Abstract]
Immunoblots for c-MYC and GSPT1 in THP1 and HL60 cells cultured with CA-4948 (10 µM) or vehicle for 14 days and then treated with the indicated GSPT1 degraders (SJ6986; 10 µM; CC-885, 0.5 nM) for 24 h.
Solvente y solubilidad
DMSO : 100 mg/mL (201.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0105 mL | 10.0523 mL | 20.1045 mL | 50.2614 mL |
| 5 mM | 0.4021 mL | 2.0105 mL | 4.0209 mL | 10.0523 mL | |
| 10 mM | 0.2010 mL | 1.0052 mL | 2.0105 mL | 5.0261 mL | |
| 15 mM | 0.1340 mL | 0.6702 mL | 1.3403 mL | 3.3508 mL | |
| 20 mM | 0.1005 mL | 0.5026 mL | 1.0052 mL | 2.5131 mL | |
| 25 mM | 0.0804 mL | 0.4021 mL | 0.8042 mL | 2.0105 mL | |
| 30 mM | 0.0670 mL | 0.3351 mL | 0.6702 mL | 1.6754 mL | |
| 40 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2565 mL | |
| 50 mM | 0.0402 mL | 0.2010 mL | 0.4021 mL | 1.0052 mL | |
| 60 mM | 0.0335 mL | 0.1675 mL | 0.3351 mL | 0.8377 mL | |
| 80 mM | 0.0251 mL | 0.1257 mL | 0.2513 mL | 0.6283 mL | |
| 100 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5026 mL |
SJ6986 Related Classifications
HY-132199 Related Classifications
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