Exatecan-methylacetamide-OH

Cat. No.: HY-156849 Pureza: 97.30%: Ficha de datos
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Exatecan-methylacetamide-OH (compound 6) is a Exatecan derivative with anticancer effects. Exatecan-methylacetamide-OH is an ADC cytotoxin that can be used to synthesize Antibody-Drug Conjugates (ADCs) (CN112125915A; compound 6).

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Exatecan-methylacetamide-OH Estructura química

No. CAS : 2594423-51-3

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas ADC Payload:

Ver todas las isoformas

Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Ver todos los productos específicos de isoformas Topoisomerase:

Ver todas las isoformas

Topoisomerase Topo I Topo II DNA gyrase

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

Camptothecins

Peso molecular

507.51

Fòrmula

C₂₇H₂₆FN₃O₆

No. CAS

2594423-51-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC(N([C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)C)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (197.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9704 mL	9.8520 mL	19.7040 mL
5 mM	0.3941 mL	1.9704 mL	3.9408 mL
10 mM	0.1970 mL	0.9852 mL	1.9704 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 97.30%

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Ficha de datos (276 KB) SDS (252 KB)

COA (261 KB) HNMR (438 KB) RP-HPLC (261 KB) LCMS (104 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yi Zhu, et al. Camptothecin derivative and conjugate thereof. CN112125915A.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9704 mL	9.8520 mL	19.7040 mL	49.2601 mL
	5 mM	0.3941 mL	1.9704 mL	3.9408 mL	9.8520 mL
	10 mM	0.1970 mL	0.9852 mL	1.9704 mL	4.9260 mL
	15 mM	0.1314 mL	0.6568 mL	1.3136 mL	3.2840 mL
	20 mM	0.0985 mL	0.4926 mL	0.9852 mL	2.4630 mL
	25 mM	0.0788 mL	0.3941 mL	0.7882 mL	1.9704 mL
	30 mM	0.0657 mL	0.3284 mL	0.6568 mL	1.6420 mL
	40 mM	0.0493 mL	0.2463 mL	0.4926 mL	1.2315 mL
	50 mM	0.0394 mL	0.1970 mL	0.3941 mL	0.9852 mL
	60 mM	0.0328 mL	0.1642 mL	0.3284 mL	0.8210 mL
	80 mM	0.0246 mL	0.1232 mL	0.2463 mL	0.6158 mL
	100 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.4926 mL