2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation Cell Cycle/DNA Damage
  3. Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS) DNA/RNA Synthesis
  4. FBP

FBP is a mitochondria-targeted, selective anticancer agent. FBP induces oxidative stress and mitochondrial dysfunction, leading to Apoptosis. FBP generates ROS and causes double-strand DNA breaks in cancer cells. FBP exhibits cytotoxic efficacy against cancer cells, with cervical cancer cells being the most sensitive. FBP can be used for the research of cervical cancer, lung cancer, melanoma and breast cancer.

For research use only. We do not sell to patients.

FBP

FBP Chemical Structure

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FBP Related Antibodies

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Description

FBP is a mitochondria-targeted, selective anticancer agent. FBP induces oxidative stress and mitochondrial dysfunction, leading to Apoptosis. FBP generates ROS and causes double-strand DNA breaks in cancer cells. FBP exhibits cytotoxic efficacy against cancer cells, with cervical cancer cells being the most sensitive. FBP can be used for the research of cervical cancer, lung cancer, melanoma and breast cancer[1].

In Vitro

FBP (50-500 μg/mL; 24 h) exhibits excellent biocompatibility with NIH3/T3 mouse embryonic fibroblasts and L929 mouse fibroblasts[1].
FBP (50-500 μg/mL; 24 h) exhibits selective concentration-dependent cytotoxicity against a variety of cancer cell lines, with the strongest activity against HeLa cervical cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FBP Related Antibodies

Cell Viability Assay[1]

Cell Line: NIH3/T3 mouse embryonic fibroblasts, L929 mouse fibroblasts
Concentration: 50-500 μg/mL
Incubation Time: 24 h
Result: Maintained cell viability above 80% at concentrations up to 200 μg/mL in both cell lines.
Reached an IC50 greater than 220 μg/mL for L929 cells.
Reached an IC50 greater than 290 μg/mL for NIH3/T3 cells.

Cell Cytotoxicity Assay[1]

Cell Line: HeLa human cervical carcinoma cells, A549 human lung adenocarcinoma cells, B16F10 mouse melanoma cells, 4T1 murine mammary carcinoma cells
Concentration: 50-500 μg/mL
Incubation Time: 24 h
Result: Induced concentration-dependent reductions in cell viability across all tested cancer cell lines.
Showed the highest sensitivity against HeLa cells, with an IC50 of 180 μg/mL and a selectivity index of 1.61 relative to NIH3/T3 cells.
Reached an IC50 of 290 μg/mL and a selectivity index of 1 against A549 cells.
Reached an IC50 of 240 μg/mL and a selectivity index of 1.20 relative to NIH3/T3 cells against B16F10 and 4T1 cells.
Molecular Weight

535.20

Formula

C24H22FeIN3
SMILES

[][Fe][].c1(C[N+]2=CN(Cc3ncccc3)C4=CC=CC=C42)cccc1.c5cccc5.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FBP Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FBPMitochondrial MetabolismApoptosisReactive Oxygen Species (ROS)DNA/RNA SynthesisNIH3/T3 mouse embryonic fibroblastsreactive oxygen speciesHeLa human cervical carcinoma cellsapoptotic cell deathsinglet oxygenA549 human lung adenocarcinoma cellsB16F10 mouse melanomaDNA double-strand breaksL929 mouse fibroblastsmitochondriaInhibitorinhibitorinhibit

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