Cat. No.: HY-N0661

Alliin

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities.

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Pureté: 99.63%
CAS No.: 556-27-4
Formule: C₆H₁₁NO₃S
Masse moléculaire:177.22

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Alliin Chemical Structure

CAS No.: 556-27-4

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities^[1]^[2].

In Vitro

Alliin (0-160 μM, 2 h) reduces lipid accumulation and ameliorates the cAMP Levels in 1,3-DCP-induced HepG2 cells^[1].
Alliin (0-160 μM, 23 h) inhibits the expression levels of proteins and genes (SREBP-1, FAS, SREBP-2 and HMGCR) involved in AMPK–SREBPs signaling pathway in HepG2 Cells^[1].
Alliin (100 μM, 6 h) inhibits p38, JNK and ERK1/2 phosphorylation and blocks MAPKs-mediated NF-κB/AP-1/STAT-1 signal transducer to improve the inflammatory responses in LPS-stimulated RAW264.7 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 cells
Concentration:

10-1280 μM
Incubation Time:

24 h
Result:

Decreased the cell viability at concentrations from 320 μM to 1280 μM.
Did not have cell toxicity at concentrations from 0 μM to 160 μM.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

0-160 μM
Incubation Time:

23 h
Result:

Increased the expression of p-AMPK and decreased the protein expression of AMPK at concentrations of 80 μM and 160 μM.
Inhibited the protein expression of SREBP-1, FAS, SREBP-2 and HMGCR by 1,3-DCP-induced at concentrations of 80 μM and 160 μM.

Western Blot Analysis^[2]

Cell Line:

RAW264.7
Concentration:

100 μg/mL
Incubation Time:

6 h
Result:

Inhibited the protein expression of iNOS, IL-1β, IL-6, and TNF-α, and the production of NO.
Suppressed the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNAs.
Blocked JNK/ERK1/2-mediated transcriptional activation of PPARγ.

In Vivo

Alliin (500 mg/kg, i.g., 10 days) ameliorates colon damage and spleen changes in DSS colitis mouse model through reduces pro-inflammatory cytokines (iNOS, TNF-α and IL-6) expression and inhibits the phosphorylation of ERK1/2, JNK, p38 and PPARγ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DSS colitis mouse model^[2]
Dosage:

500 mg/kg
Administration:

i.g., 10 days
Result:

Decrease hematochezia symptom and diarrhea symptom.
Improved weight loss.
Reduced colon injury and inflammatory cell infiltration, restored the structure of colon epithelial and crypt.
Reduced the expression of iNOS, TNF-α and IL-6 mRNAs.

Chemical Information

CAS No. 556-27-4
Appearance Solid
Masse moléculaire 177.22
Formule C₆H₁₁NO₃S
Color White to off-white
SMILES

N[C@@H](C[S@](CC=C)=O)C(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Food Sci Nutr

Effect of Thermal Treatment on the Antiproliferative and Antioxidant Activities of Garlic. [Abstract]

2025 Jun 6;13(6):e70375. PMID: 40488192

Solvant et solubilité

In Vitro:

H₂O : 250 mg/mL (1410.68 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.6427 mL

28.2135 mL

56.4270 mL

5 mM

1.1285 mL

5.6427 mL

11.2854 mL

10 mM

0.5643 mL

2.8214 mL

5.6427 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (564.27 mM); Clear solution; Need ultrasonic

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lu J, et al. Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. Life Sci. 2018 Feb 15;195:19-24. [Content Brief]

[2]. Shi L, et al. Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. Mol Nutr Food Res. 2017 Sep;61(9). [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.6427 mL	28.2135 mL	56.4270 mL	141.0676 mL
	5 mM	1.1285 mL	5.6427 mL	11.2854 mL	28.2135 mL
	10 mM	0.5643 mL	2.8214 mL	5.6427 mL	14.1068 mL
	15 mM	0.3762 mL	1.8809 mL	3.7618 mL	9.4045 mL
	20 mM	0.2821 mL	1.4107 mL	2.8214 mL	7.0534 mL
	25 mM	0.2257 mL	1.1285 mL	2.2571 mL	5.6427 mL
	30 mM	0.1881 mL	0.9405 mL	1.8809 mL	4.7023 mL
	40 mM	0.1411 mL	0.7053 mL	1.4107 mL	3.5267 mL
	50 mM	0.1129 mL	0.5643 mL	1.1285 mL	2.8214 mL
	60 mM	0.0940 mL	0.4702 mL	0.9405 mL	2.3511 mL
	80 mM	0.0705 mL	0.3527 mL	0.7053 mL	1.7633 mL
	100 mM	0.0564 mL	0.2821 mL	0.5643 mL	1.4107 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Alliin

3 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Alliin

Activité biologique

Chemical Information

Publications (3)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Alliin Related Classifications

HY-N0661 Related Classifications