Cat. No.: HY-111055

BIP-135

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BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC₅₀s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

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Pureté: 99.38%
CAS No.: 941575-71-9
Formule: C₂₁H₁₃BrN₂O₃
Masse moléculaire:421.24

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BIP-135 Chemical Structure

CAS No.: 941575-71-9

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
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Activité biologique

Description

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC₅₀s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect^[1].

IC₅₀ & Target

GSK-3α

16 nM (IC₅₀)

GSK-3β

21 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform GSK-3 :

Cellular Effect

Cell Line	Type	Value	Description	References
HuP-T3	IC₅₀	43 μM Compound: 13	Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay	[PMID: 19338355]
MIA PaCa-2	IC₅₀	30 μM Compound: 13	Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay	[PMID: 19338355]

In Vitro

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations^[1].
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human SMA fibroblasts
Concentration:

20 μM, 25 μM, 30 μM
Incubation Time:

72 hours
Result:

Led to a 7-fold increase in SMN levels at 25 μM.

In Vivo

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)^[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male and female SMN2^+/+, SMN2Δ7^+/+, Smn^+/– mice^[1]
Dosage:

75 mg/kg
Administration:

Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:

Caused a modest extension in the median survival of SMA KO animals by two days.

Chemical Information

CAS No. 941575-71-9
Appearance Solid
Masse moléculaire 421.24
Formule C₂₁H₁₃BrN₂O₃
Color Light yellow to orange
SMILES

O=C(C(C1=COC2=CC=CC=C12)=C3C4=CN(C)C5=C4C=C(Br)C=C5)NC3=O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 62.5 mg/mL (148.37 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3739 mL

11.8697 mL

23.7394 mL

5 mM

0.4748 mL

2.3739 mL

4.7479 mL

10 mM

0.2374 mL

1.1870 mL

2.3739 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen PC, et al. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18;3(1):5-11. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3739 mL	11.8697 mL	23.7394 mL	59.3486 mL
	5 mM	0.4748 mL	2.3739 mL	4.7479 mL	11.8697 mL
	10 mM	0.2374 mL	1.1870 mL	2.3739 mL	5.9349 mL
	15 mM	0.1583 mL	0.7913 mL	1.5826 mL	3.9566 mL
	20 mM	0.1187 mL	0.5935 mL	1.1870 mL	2.9674 mL
	25 mM	0.0950 mL	0.4748 mL	0.9496 mL	2.3739 mL
	30 mM	0.0791 mL	0.3957 mL	0.7913 mL	1.9783 mL
	40 mM	0.0593 mL	0.2967 mL	0.5935 mL	1.4837 mL
	50 mM	0.0475 mL	0.2374 mL	0.4748 mL	1.1870 mL
	60 mM	0.0396 mL	0.1978 mL	0.3957 mL	0.9891 mL
	80 mM	0.0297 mL	0.1484 mL	0.2967 mL	0.7419 mL
	100 mM	0.0237 mL	0.1187 mL	0.2374 mL	0.5935 mL

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BIP-135

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Voir tous les produits spécifiques à Isoform GSK-3

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

BIP-135 Related Classifications

Cat. No.: HY-111055