G2iA
G2iA is a selective GLUT2 inhibitor that inhibits GLUT2-mediated glucose transport with an IC50 of 0.61 µM.
For research use only. We do not sell to patients.
- CAS No.: 536702-12-2
- Formula: C27H24FN3O2S
- Molecular Weight:473.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
GLUT2 0.61 μM (IC50) |
In Vitro
G2iA inhibits glucose uptake via human GLUT2∆loopS_Q455R expressed in the hxt0 yeast strain EBY.S7, with an IC50 of 0.61 µM, and acts as a noncompetitive inhibitor with respect to glucose[1].
G2iA (100 µM; 10 min) is a GLUT2-selective inhibitor that, at a concentration of 100 µM, does not significantly inhibit GLUT1, GLUT3, GLUT4, or GLUT5 in hxt0 yeast transport assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 536702-12-2
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Molecular Weight 473.56
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Formula C27H24FN3O2S
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SMILES
O=C(CSC1=C(C)NC2=C1C=CC=C2)N3N=C(CC3C4=CC=C(C=C4)F)C5=CC=C(OC)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G2iA Related Classifications
HY-189099 Related Classifications
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