AZ1729
AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathways, but not at those transduced by Gq/G11. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2.
For research use only. We do not sell to patients.
- CAS No.: 2016864-46-1
- Formula: C18H16FN5OS
- Molecular Weight:369.42
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-116263
CATPBFFA2R Antagonist -
HY-P1125
4-CMTBFFA2 Agonist -
HY-50691
GW-1100Free Fatty Acid Receptor Antagonist -
HY-P1123
MEDICA16Acetyl-CoA Carboxylase/ATP-Citrate Lyase Inhibitor -
HY-P1123R
MEDICA16 (Standard)Free Fatty Acid Receptor Agonist -
HY-50691R
GW-1100 (Standard)Free Fatty Acid Receptor Antagonist -
HY-129707
AMG 837 hemicalciumGPR40/FFA1 Inhibitor -
HY-P1124
AS2034178 free baseFree Fatty Acid Receptor Agonist
Biological Activity
Description
IC50 & Target
FFA2[1]
Chemical Information
-
CAS No. 2016864-46-1
-
Appearance Solid
-
Molecular Weight 369.42
-
Formula C18H16FN5OS
-
Color Light yellow to yellow
-
SMILES
O=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
-
Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.
-
Large-size fat particle sorting
Large-size fat particle sorting is widely used to isolate cells up to 200 μm in diameter. Single-cell flow sorting will allow greater insight into adipocyte heterogeneity by identifying gene expression, protein composition, and metabolic signatures at the single-cell level.
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ1729 Related Classifications
HY-121140 Related Classifications
Powered by Bioz