Dalmitamig
Based on 1 Customer Validation
HY-P990913 is an EGFR/CD28-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
For research use only. We do not sell to patients.
- Purity: 97.158%
- CAS No.: 2765077-69-6
- Molecular Weight:145.24 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
EGFR & CD28
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG4-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized EGFR Protein, Human (sf9, His-GST, HY-P72987) can bind Dalmitamig. The EC50 for this effect is 686.8 ng/mL. -
Immobilized CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, HY-P74313) can bind Dalmitamig. The EC50 for this effect is 791.3 ng/mL. -
Flow cytometric analysis of 1X106 Juakat cells with Dalmitamig (HY-P990913, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2765077-69-6
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Appearance Liquid
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Molecular Weight 145.24 kDa
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Color Colorless to light yellow
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SMILES
[Dalmitamig]
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Synonyms
bsAb7075; REGN-7075; Marlotamig
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (254 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)