17-HETE
17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 128914-47-6
- Fòrmula: C20H32O3
- Peso molecular:320.47
-
Almacenamiento:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
CYP1B1 |
17-HETE (5-20 μM) promotes the development of cardiac hypertrophy in human, through increasing CY1B1 at activity and protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:New Zealand White rabbit[2]
-
Dosage:1-20 μg
-
Administration:injection into artery
-
Result:17S inhibited more than 70% ATPase activity at the concentration of 2 μM, while 17R enantiomer remained inactive.
Chemical Information
-
No. CAS 128914-47-6
-
Appearance Liquid
-
Peso molecular 320.47
-
Fòrmula C20H32O3
-
Color Colorless to light yellow
-
SMILES
CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
-
Ficha de datos (266 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [Content Brief]
[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
17-HETE Related Classifications
HY-116196 Related Classifications
Powered by Bioz