Cefonicid sodium
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Cefonicid sodium is a long-acting cephalosporin antibiotic. Cefonicid sodium also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid sodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid sodium can be used for research on infections.
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- Pureza : 95.0%
- No. CAS: 61270-78-8
- Fòrmula: C18H16N6Na2O8S3
- Peso molecular:586.53
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Cefonicid sodium (25-200 mg/L; 3-6 days) dose-dependently inhibits the proliferation of human PBMCs stimulated by FLU, XENO, ALLO, and PHA (HY-N7038)[1].
Cefonicid sodium (0-200 mg/L; 7 days) dose-dependently inhibits IL-2 production by human PBMC stimulated with FLU, XENO and ALLO[1].
Cefonicid sodium (0-24 h) exhibits concentration-dependent bactericidal activity against Klebsiella pneumoniae strain 2603 in vitro, with an MIC of 0.25 mg/L[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Cefonicid sodium (40 mg/kg; single dose) exhibits excellent protective effects against S. aureus, E. coli, P. mirabilis, and K. pneumoniae infections in mice[4].
Cefonicid sodium exerts excellent preventive protective effects against surgical wound infections in mice, with an ED50 value of ≤2.1 mg/kg against Gram-negative bacilli and an ED50 value ranging from 3.7 to 8.7 mg/kg against S. aureus[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hartley (female, 220-250 g)[3]
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Dosage:15 mg/kg
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Administration:i.p.; 2 doses (immediately and 24 hours post-challenge)
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Result:Showed similar lung bacterial counts to infected untreated controls at 0 and 1 hour post-challenge.
Reduced lung bacterial counts significantly compared to infected untreated controls starting at 6 hours post-challenge, with significant reductions also seen at 24 and 48 hours post-challenge.
Chemical Information
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No. CAS 61270-78-8
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Appearance Solid
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Peso molecular 586.53
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Fòrmula C18H16N6Na2O8S3
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Color White to off-white
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SMILES
O=C(C(N12)=C(CSC3=NN=NN3CS(=O)(O[Na])=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O)O[Na]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
In Vitro:
DMSO : 116.67 mg/mL (198.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (170.49 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]
[4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.7049 mL | 8.5247 mL | 17.0494 mL | 42.6236 mL |
| 5 mM | 0.3410 mL | 1.7049 mL | 3.4099 mL | 8.5247 mL | |
| 10 mM | 0.1705 mL | 0.8525 mL | 1.7049 mL | 4.2624 mL | |
| 15 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8416 mL | |
| 20 mM | 0.0852 mL | 0.4262 mL | 0.8525 mL | 2.1312 mL | |
| 25 mM | 0.0682 mL | 0.3410 mL | 0.6820 mL | 1.7049 mL | |
| 30 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 40 mM | 0.0426 mL | 0.2131 mL | 0.4262 mL | 1.0656 mL | |
| 50 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8525 mL | |
| 60 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7104 mL | |
| 80 mM | 0.0213 mL | 0.1066 mL | 0.2131 mL | 0.5328 mL | |
| 100 mM | 0.0170 mL | 0.0852 mL | 0.1705 mL | 0.4262 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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