DO34 analog
Based on 1 Customer Validation
DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB1 receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.42%
- No. CAS: 2098969-71-0
- Fòrmula: C26H28F3N5O4
- Peso molecular:531.53
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
DAGLα 6 nM (IC50) |
DAGLβ |
In Vitro
Chemical Information
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No. CAS 2098969-71-0
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Appearance Solid
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Peso molecular 531.53
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Fòrmula C26H28F3N5O4
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Color Light yellow to yellow
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SMILES
O=C(N1C(CC2=CC=CC=C2)CN(C(OC(C)(C)C)=O)CC1)N3N=CC(C4=CC=C(OC(F)(F)F)C=C4)=N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : ≥ 105 mg/mL (197.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Deng H, et al. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem. 2017;60(1):428-440. [Content Brief]
[2]. Liu X, et al. Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. Sci Rep. 2016;6:35829. Published 2016 Oct 24. [Content Brief]
[3]. Ogasawara D, et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci U S A. 2016;113(1):26-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8814 mL | 9.4068 mL | 18.8136 mL | 47.0340 mL |
| 5 mM | 0.3763 mL | 1.8814 mL | 3.7627 mL | 9.4068 mL | |
| 10 mM | 0.1881 mL | 0.9407 mL | 1.8814 mL | 4.7034 mL | |
| 15 mM | 0.1254 mL | 0.6271 mL | 1.2542 mL | 3.1356 mL | |
| 20 mM | 0.0941 mL | 0.4703 mL | 0.9407 mL | 2.3517 mL | |
| 25 mM | 0.0753 mL | 0.3763 mL | 0.7525 mL | 1.8814 mL | |
| 30 mM | 0.0627 mL | 0.3136 mL | 0.6271 mL | 1.5678 mL | |
| 40 mM | 0.0470 mL | 0.2352 mL | 0.4703 mL | 1.1759 mL | |
| 50 mM | 0.0376 mL | 0.1881 mL | 0.3763 mL | 0.9407 mL | |
| 60 mM | 0.0314 mL | 0.1568 mL | 0.3136 mL | 0.7839 mL | |
| 80 mM | 0.0235 mL | 0.1176 mL | 0.2352 mL | 0.5879 mL | |
| 100 mM | 0.0188 mL | 0.0941 mL | 0.1881 mL | 0.4703 mL |
DO34 analog Related Classifications
HY-117771A Related Classifications
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