GPR120 modulator 2
Based on 1 Customer Validation
GPR120 modulator 2 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F13. GPR120 modulator 2 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.11%
- No. CAS: 1050506-87-0
- Fòrmula: C20H18ClNO3S
- Peso molecular:387.88
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-50162
GPR120 modulator 1 -
HY-101492
GPR120 Agonist 3 -
HY-114610
13Z,16Z-Docosadienoic acid -
HY-19995
GSK137647A -
HY-N0040
Ginsenoside Rb2 -
HY-101492R
GPR120 Agonist 3 (Standard) -
HY-100881
TUG-891 -
HY-111353
GPR120 Agonist 2 -
HY-50691
GW-1100 -
HY-101906
DC260126 -
HY-100775
Fezagepras sodium -
HY-13967B
AMG 837 calcium hydrate
Actividad biológica
Descripciòn
IC50 & Target
GPR120[1]
Chemical Information
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No. CAS 1050506-87-0
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Appearance Solid
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Peso molecular 387.88
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Fòrmula C20H18ClNO3S
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Color White to off-white
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SMILES
O=C(O)CCC1=CC=C(OCC2=NC(C3=CC=CC=C3Cl)=CS2)C=C1C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (257.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3 mg/mL (7.73 mM); Clear solution
This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5781 mL | 12.8906 mL | 25.7812 mL | 64.4529 mL |
| 5 mM | 0.5156 mL | 2.5781 mL | 5.1562 mL | 12.8906 mL | |
| 10 mM | 0.2578 mL | 1.2891 mL | 2.5781 mL | 6.4453 mL | |
| 15 mM | 0.1719 mL | 0.8594 mL | 1.7187 mL | 4.2969 mL | |
| 20 mM | 0.1289 mL | 0.6445 mL | 1.2891 mL | 3.2226 mL | |
| 25 mM | 0.1031 mL | 0.5156 mL | 1.0312 mL | 2.5781 mL | |
| 30 mM | 0.0859 mL | 0.4297 mL | 0.8594 mL | 2.1484 mL | |
| 40 mM | 0.0645 mL | 0.3223 mL | 0.6445 mL | 1.6113 mL | |
| 50 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2891 mL | |
| 60 mM | 0.0430 mL | 0.2148 mL | 0.4297 mL | 1.0742 mL | |
| 80 mM | 0.0322 mL | 0.1611 mL | 0.3223 mL | 0.8057 mL | |
| 100 mM | 0.0258 mL | 0.1289 mL | 0.2578 mL | 0.6445 mL |
GPR120 modulator 2 Related Classifications
HY-50172 Related Classifications
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