Imazalil
Based on 1 publication(s) in Google Scholar
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
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- Pureza: 99.54%
- No. CAS: 35554-44-0
- Fòrmula: C14H14Cl2N2O
- Peso molecular:297.18
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Imazalil
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Actividad biológica
Imazalil (Enilconazole; 3, 10, 30 μM; for 6 h) significantly suppressed IL-17 mRNAs[1].
imazalil (1, 3, 10, 30, 100 μM; for 24 h) dose-dependently induces the reporter gene expression only in mPXR-expressed HepG2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:EL4 cells
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Concentration:3, 10, 30 μM
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Incubation Time:6 h
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Result:Significantly suppressed IL-17 mRNAs.
Imazalil (75 mg/kg; ip; twice; once a day) combined with TCPOBOP (3 mg/kg) much greatly increased the number of Ki-67-positive nuclei and Mcm2 mRNA levels compared to its single treatment. Imazalil accelerates hepatocyte proliferation mediated by TCPOBOP treatment in mice[2].
Imazalil (0.1, 0.5, or 2.5 mg/kg in drinking water for 15 weeks) induces oxidative stress and caused the disorders of bile acid metabolism in male adult C57BL/6 mice [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:IMZ Male C57BL/6N mice[2]
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Dosage:25, 50, 75, 100 mg/kg
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Administration:Intraperitoneally; single dose
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Result:Significantly increased hepatic Cyp3a11 mRNA levels in a dose-dependent manner.
Chemical Information
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No. CAS 35554-44-0
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Appearance Solid
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Peso molecular 297.18
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Fòrmula C14H14Cl2N2O
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Color Light yellow to yellow
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SMILES
C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2
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Synonyms
Enilconazole
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Matrix-Assisted Laser Desorption Ionization Imaging and Laser Ablation Sampling for Analysis of Fungicide Distribution in Apples. [Abstract]2019 May 7;91(9):6051-6056. PMID: 30969757
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (336.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (67.30 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 1 mg/mL (3.36 mM); Suspended solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (785 KB)
- English - EN (785 KB)
- Français - FR (785 KB)
- Deutsch - DE (785 KB)
- Norwegian - NO (785 KB)
- Español - ES (785 KB)
- Swedish - SV (785 KB)
- Italian - IT (785 KB)
- Korean - KR (785 KB)
- Portuguese - PT (785 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45. [Content Brief]
[2]. Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450. [Content Brief]
[3]. Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.3650 mL | 16.8248 mL | 33.6496 mL | 84.1241 mL |
| 5 mM | 0.6730 mL | 3.3650 mL | 6.7299 mL | 16.8248 mL | |
| 10 mM | 0.3365 mL | 1.6825 mL | 3.3650 mL | 8.4124 mL | |
| 15 mM | 0.2243 mL | 1.1217 mL | 2.2433 mL | 5.6083 mL | |
| 20 mM | 0.1682 mL | 0.8412 mL | 1.6825 mL | 4.2062 mL | |
| 25 mM | 0.1346 mL | 0.6730 mL | 1.3460 mL | 3.3650 mL | |
| 30 mM | 0.1122 mL | 0.5608 mL | 1.1217 mL | 2.8041 mL | |
| 40 mM | 0.0841 mL | 0.4206 mL | 0.8412 mL | 2.1031 mL | |
| 50 mM | 0.0673 mL | 0.3365 mL | 0.6730 mL | 1.6825 mL | |
| 60 mM | 0.0561 mL | 0.2804 mL | 0.5608 mL | 1.4021 mL | |
| DMSO | 80 mM | 0.0421 mL | 0.2103 mL | 0.4206 mL | 1.0516 mL |
| 100 mM | 0.0336 mL | 0.1682 mL | 0.3365 mL | 0.8412 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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