MIV-150
MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 231957-54-3
- Fòrmula: C19H17FN4O3
- Peso molecular:368.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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HY-10570
NevirapineHIV-1 Reverse Transcriptase Inhibitor -
HY-10574
RilpivirineNNRTI -
HY-90005
Etravirine -
HY-10570R
Nevirapine (Standard)HIV-1 Reverse Transcriptase Inhibitor -
HY-14267
LersivirineNNRTI -
HY-104012
IslatravirNucleoside Reverse Transcriptase Translocation Inhibitor -
HY-90005R
Etravirine (Standard) -
HY-10574R
Rilpivirine (Standard)NNRTI -
HY-104012R
Islatravir (Standard)Reference Standard
Actividad biológica
Descripciòn
IC50 & Target
[1]|
HIV-1 <1 nM (EC50) |
HIV-2 <1 nM (EC50) |
In Vitro
The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 231957-54-3
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Peso molecular 368.36
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Fòrmula C19H17FN4O3
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SMILES
O=C(N[C@@H]1[C@H](C2=C(F)C=CC(C(CC)=O)=C2O)C1)NC3=NC=C(C#N)C=C3
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Synonyms
PC 815
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MIV-150 Related Classifications
HY-19378 Related Classifications
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