Ronidazole
Based on 2 publication(s) in Google Scholar
Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus in cats models. Ronidazole can be used the research of forhistomoniasis and swine dysentery.
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- Pureza: 99.81%
- No. CAS: 7681-76-7
- Fòrmula: C6H8N4O4
- Peso molecular:200.15
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) Ronidazole
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Actividad biológica
Ronidazole (0.0625-0.25 μg/mL;48 hours) can effectively inhibit the growth of C. difficile all 24 strains, and the MIC50 and MIC90 values are 0.125 μg/mL.[2].
Ronidazole (0.3125 μg/mL, 1.25 μg/mL; 8 hours) can reduce the C. difficile bacteria count to below the detection limit, and has concentration-dependent bactericidal activity against C. difficile bacteria[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis in six cats[3]
| Drug administration | Dose (mg/kg) | T1/2 (K) (h) | C0 (μg/mL) | AUC 0-∞ (h•μg/m) | Vd or Vd/F (mL/kg) | Clearance or CL/F (h) | MRT (h) | Tmax (h) | Cmax (μg/m) | F (%) |
| i.v. | 9.175 | 9.80 | 13.27 | 187.30 | 700 | 0.82 | 14.14 | NA | NA | NA |
| p.o. | 28.23 | 10.50 | NA | 566.98 | 770 | 0.84 | NA | 1.02 | 35.37 | 99.64 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CDI mice model[2]
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Dosage:1 mg/kg, 10mg/kg
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Administration:Oral gavage
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Result:Both 1 mg/kg and 10 mg/kg Ronidazole protected 60% of mice from infection
Chemical Information
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No. CAS 7681-76-7
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Appearance Solid
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Peso molecular 200.15
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Fòrmula C6H8N4O4
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Color White to yellow
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SMILES
NC(OCC1=NC=C([N+]([O-])=O)N1C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Zebrafish
Ronidazole Is a Superior Prodrug to Metronidazole for Nitroreductase-Mediated Hepatocytes Ablation in Zebrafish Larvae. [Abstract]2023 Jun;20(3):95-102. PMID: 37229597 -
Solvente y solubilidad
DMSO : 100 mg/mL (499.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 4 mg/mL (19.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 5 mg/mL (24.98 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jody L Gookin, et al. Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection. J Vet Intern Med [Content Brief]
[2]. AbdelKhalek A, et al. Repurposing the Veterinary Antiprotozoal Drug Ronidazole for the Treatment of Clostridioides difficile Infection. Int J Antimicrob Agents. 2020;56(6):106188. [Content Brief]
[3]. LeVine DN, et al. Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats. J Feline Med Surg. 2011;13(4):244-250. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.9963 mL | 24.9813 mL | 49.9625 mL | 124.9063 mL |
| 5 mM | 0.9993 mL | 4.9963 mL | 9.9925 mL | 24.9813 mL | |
| 10 mM | 0.4996 mL | 2.4981 mL | 4.9963 mL | 12.4906 mL | |
| 15 mM | 0.3331 mL | 1.6654 mL | 3.3308 mL | 8.3271 mL | |
| DMSO | 20 mM | 0.2498 mL | 1.2491 mL | 2.4981 mL | 6.2453 mL |
| 25 mM | 0.1999 mL | 0.9993 mL | 1.9985 mL | 4.9963 mL | |
| 30 mM | 0.1665 mL | 0.8327 mL | 1.6654 mL | 4.1635 mL | |
| 40 mM | 0.1249 mL | 0.6245 mL | 1.2491 mL | 3.1227 mL | |
| 50 mM | 0.0999 mL | 0.4996 mL | 0.9993 mL | 2.4981 mL | |
| 60 mM | 0.0833 mL | 0.4164 mL | 0.8327 mL | 2.0818 mL | |
| 80 mM | 0.0625 mL | 0.3123 mL | 0.6245 mL | 1.5613 mL | |
| 100 mM | 0.0500 mL | 0.2498 mL | 0.4996 mL | 1.2491 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ronidazole Related Classifications
HY-B0565 Related Classifications
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