IDE

IDE (Insulin-degrading enzyme) is a Zn²⁺-dependent endopeptidase with insulin-degrading activity, belonging to the peptidase M16 family. IDE regulates blood glucose homeostasis by lowering insulin levels, while also participating in peptide hormone signaling cascades by degrading a variety of other important peptides, including APP-derived peptides, IAPP, Glucagon, natriuretic peptides (ANP, BNP, CNP), Bradykinin, Kallidin, and others. Additionally, IDE plays a crucial role in clearing Aβ plaques accumulated in the brain, which may alleviate cognitive impairments and neurodegenerative diseases associated with Aβ. IDE is also involved in antigen processing, degrading MAGEA3-derived peptides to produce antigenic peptides that are presented to cytotoxic T lymphocytes, contributing to the immune response.
IDE is an important enzyme in regulating various hormone and peptide signaling pathways and plays a critical role in research related to metabolic diseases, neurodegenerative diseases, cardiovascular diseases, and immune-related diseases^[1].