α-Cyclodextrin
Based on 2 publication(s) in Google Scholar
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids.
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- Pureza: 99.96%
- No. CAS: 10016-20-3
- Fòrmula: C36H60O30
- Peso molecular:972.84
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) α-Cyclodextrin
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Actividad biológica
α-Cyclodextrin exerts a protective effect against SARS-CoV-2 infection in Vero E6 cells at non-cytotoxic concentrations[2].
α-Cyclodextrin (6.25-50 μM, 24 h) enhances the antitumor effect of Crcumin (HY-N0005) on MCF-7, A549 and HeLa cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, A549 and HeLa cells
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Concentration:6.25, 12.5, 25, 50 μM
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Incubation Time:24 h
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Result:Enhanced the anti-tumor efficacy of curcumin after inclusion with curcumina.
α-Cyclodextrin (diets containing 0-20% α-Cyclodextrin, p.o., 13 weeks) is well tolerated in the Beagle dogs, but diarrhea occurred[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 10016-20-3
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Appearance Solid
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Peso molecular 972.84
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Fòrmula C36H60O30
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Color White to off-white
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SMILES
OC[C@@H](O[C@@](O[C@]([C@@H]1O)([H])[C@H](O[C@@](O[C@]([C@@H]2O)([H])[C@H](O[C@@](O[C@@]3([H])[C@@H]4O)([H])[C@@H]2O)CO)([H])[C@@H]1O)CO)([H])[C@@H]5O)[C@](O[C@](O[C@H](CO)[C@](O[C@](O[C@H](CO)[C@](O[C@](O[C@@H]3CO)([H])[C@@H]4O)([H])[C@@H]6O)([H])[C@@H]6O)([H])[C@@H]7O)([H])[C@@H]7O)([H])[C@@H]5O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Immunity
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING. [Abstract]2021 May 11;54(5):962-975.e8. PMID: 33857420 -
J Am Chem Soc
2018 Dec 12;140(49):17234-17240. PMID: 30398334
Solvente y solubilidad
DMSO : 110 mg/mL (113.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 35 mg/mL (35.98 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (293 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Comerford KB, et al. The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans. Obesity (Silver Spring). 2011 Jun;19(6):1200-4. [Content Brief]
[2]. Paolacci S, et al. In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection. Eur Rev Med Pharmacol Sci. 2021 Dec;25(1 Suppl):81-89. [Content Brief]
[3]. Jana B, et al. α-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell. ACS Appl Mater Interfaces. 2016 Jun 8;8(22):13793-803. [Content Brief]
[4]. Lina BA, et al. Subchronic oral toxicity studies with alpha-cyclodextrin in rats. Regul Toxicol Pharmacol. 2004 Jun;39 Suppl 1:S14-26. [Content Brief]
[5]. Lina BA, et al. Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs. Regul Toxicol Pharmacol. 2004 Jun;39 Suppl 1:S27-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.0279 mL | 5.1396 mL | 10.2792 mL | 25.6980 mL |
| 5 mM | 0.2056 mL | 1.0279 mL | 2.0558 mL | 5.1396 mL | |
| 10 mM | 0.1028 mL | 0.5140 mL | 1.0279 mL | 2.5698 mL | |
| 15 mM | 0.0685 mL | 0.3426 mL | 0.6853 mL | 1.7132 mL | |
| 20 mM | 0.0514 mL | 0.2570 mL | 0.5140 mL | 1.2849 mL | |
| 25 mM | 0.0411 mL | 0.2056 mL | 0.4112 mL | 1.0279 mL | |
| 30 mM | 0.0343 mL | 0.1713 mL | 0.3426 mL | 0.8566 mL | |
| DMSO | 40 mM | 0.0257 mL | 0.1285 mL | 0.2570 mL | 0.6424 mL |
| 50 mM | 0.0206 mL | 0.1028 mL | 0.2056 mL | 0.5140 mL | |
| 60 mM | 0.0171 mL | 0.0857 mL | 0.1713 mL | 0.4283 mL | |
| 80 mM | 0.0128 mL | 0.0642 mL | 0.1285 mL | 0.3212 mL | |
| 100 mM | 0.0103 mL | 0.0514 mL | 0.1028 mL | 0.2570 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Cyclodextrin Related Classifications
HY-B1513 Related Classifications
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