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Referencia número: HY-179119

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AB19

AB19 is a potent Vav1 inhibitor. AB19 inhibits Vav1 and reduces its downstream ERK phosphorylation. AB19 shows anti-proliferative activity in pancreatic cancer models. AB19 can be used for pancreatic cancer research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₈H₄₆BrNO₄
Peso molecular:540.57

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

AB19 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas ERK :

In Vitro

AB19 (0-1 μM, 4 days) exhibits antitumoral activity in Vav1 positive pancreatic cancer lines, including CAPAN-2, MIA PaCa-2, and CFPAC cells^[1].
AB19 (0.1-1 μM) reduces Vav1 expression and inhibits ERK phosphorylation in CAPAN-2 cells^[1].
AB19 (0-1 μM, 5 days) exhibits antitumoral activity in pancreatic cancer patient-derived organoids (PDOs), showing greater potency in Vav1 high-expressing HO219 compared to the low-expressing HO163 model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CAPAN-2, MIA PaCa-2, CFPAC, ASPC-1, and HPNE cells
Concentration:

0, 0.1, and 1 μM
Incubation Time:

4 days
Result:

Showed a reduction in Vav1 positive cell (CAPAN-2, MIA PaCa-2, and CFPAC) numbers relative to the control at 1 μM.
Showed no effect on Vav1 negative ASPC-1 and HPNE cells.

Chemical Information

Peso molecular 540.57
Fòrmula C₂₈H₄₆BrNO₄
SMILES

CCCCCCCCCCCCCC[N+]1=CC=C(OCC(C/C2=C(C)\C)(CO)OC2=O)C=C1.[Br-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Bellomo A, et al. Novel DAG-Lactone-Based Vav1 Inhibitors Show Anti-proliferative Activity in Pancreatic Cancer Models. ChemMedChem. 2025 Oct 20:e202500589. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AB19

Ver todos los productos específicos de isoformas ERK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

AB19 Related Classifications

HY-179119 Related Classifications