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Referencia número: HY-111072

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ADS103317

ADS103317 is an analog of Afatinib (HY-10261). ADS103317 weakly inhibits MCH-1R. Afatinib is an EGFR inhibitor. ADS103317 can be used in research related to non-small cell lung cancer.

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No. CAS: 934474-97-2
Fòrmula: C₂₁H₂₁ClN₄O₂
Peso molecular:396.88

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Please store the product under the recommended conditions in the Certificate of Analysis.

ADS103317 Chemical Structure

No. CAS: 934474-97-2

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Descripciòn

ADS103317 is an analog of Afatinib (HY-10261). ADS103317 weakly inhibits MCH-1R. Afatinib is an EGFR inhibitor. ADS103317 can be used in research related to non-small cell lung cancer^[1]^[2].

Ver todos los productos específicos de isoformas EGFR :

In Vitro

ADS103317 (1 μM) shows minimal inhibition (7%) of ¹²⁵I-[Phe¹³,Tyr¹⁹]-MCH binding to human MCH-1R membranes at 1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 934474-97-2
Peso molecular 396.88
Fòrmula C₂₁H₂₁ClN₄O₂
SMILES

O=C(NC=1C=CC2=NC(=NC(=C2C1)C)N3CCCC3)COC=4C=CC=C(Cl)C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Gudala S, et al. Identification and Pharmacological Analysis of High Efficacy Small Molecule Inhibitors of EGF-EGFR Interactions in Clinical Treatment of Non-Small Cell Lung Carcinoma: a Computational Approach. Asian Pac J Cancer Prev. 2015;16(18):8191-8196. [Content Brief]

[2]. Arienzo R, et al. Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ADS103317

Ver todos los productos específicos de isoformas EGFR

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ADS103317 Related Classifications

HY-111072 Related Classifications