AK305
AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a Ki of 0.4 μM for STAT6 and a Ki of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2982853-56-3
- Fòrmula: C35H40F2N5O7PS2
- Peso molecular:775.82
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
STAT6 0.4 μM (Ki) |
STAT5a 1 μM (Ki) |
STAT5b 1 μM (Ki) |
STAT5 |
In Vitro
AK305 binds with equal affinity to purified STAT5A and STAT5B proteins (Ki = 1.0 μM) and with higher affinity to purified STAT6 protein (Ki = 0.4 μM)[1].
AK305 (5 μM; 18 h) does not alter the levels of any STAT family proteins in SKNO1 AML cells[1].
AK305 (5 μM; 6 h) does not alter the levels of any STAT family proteins in MV4;11 AML cells[1].
AK305 (15 μM; 4 days) does not inhibit cell growth in SKNO1, Kasumi-3, or MV4;11 AML cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:SKNO1 acute myeloid leukemia (AML) cells
-
Concentration:5 μM
-
Incubation Time:18 h
-
Result:Exerted no effect on the levels of STAT5A, STAT5B, phosphorylated STAT5 (pSTAT5ᵞ694), STAT1, STAT2, STAT3, STAT4, or STAT6 proteins.
-
Cell Line:MV4;11 acute myeloid leukemia (AML) cells
-
Concentration:5 μM
-
Incubation Time:6 h
-
Result:Exerted no effect on the levels of STAT5, phosphorylated STAT5 (pSTAT5ᵞ694), STAT1, STAT2, STAT3, or STAT6 proteins.
Chemical Information
-
No. CAS 2982853-56-3
-
Peso molecular 775.82
-
Fòrmula C35H40F2N5O7PS2
-
SMILES
FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N(CCC(N(C)C)=O)C4=CC=C(C5=NC=CS5)C=C4)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AK305 Related Classifications
HY-184991 Related Classifications
Powered by Bioz