Amquinate
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).
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- No. CAS: 17230-85-2
- Fòrmula: C18H24N2O3
- Peso molecular:316.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Amquinate potently inhibits succinate- and NADH-supported respiration in wild-type Eimeria tenella mitochondria with an IC50 of 1×10-8 M, has no effect on chicken liver mitochondrial respiration at concentrations >1×10-3 M, and does not inhibit succinate dehydrogenase-CoQ reductase or NADH dehydrogenase-CoQ reductase activities at 1×10-4 M[1].
Amquinate shows 100-fold reduced sensitivity in mitochondria from the amquinate-resistant Eimeria tenella mutant, with an IC50 of 1×10-6 M for succinate-supported respiration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Amquinate (2000 ppm; diets) requires a 66.7-fold higher minimal effective dietary dose (2000 ppm) to exhibit anticoccidial activity against amquinate-resistant Eimeria tenella mutant infection in chickens compared to wild-type parasites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eimeria tenella[1]
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Dosage:30 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against wild-type Eimeria tenella infection.
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Animal Model:Amquinate-resistant Eimeria tenella mutant[1]
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Dosage:2000 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.
Chemical Information
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No. CAS 17230-85-2
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Peso molecular 316.40
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Fòrmula C18H24N2O3
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SMILES
O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
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Structure Classification
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Initial Source
Mitochondria from Eimeria tenella
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amquinate Related Classifications
HY-114625 Related Classifications
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