Anticancer agent 316
Anticancer agent 316 (Compound 1) is an anticancer agent. Anticancer agent 316 exerts anticancer activity against colorectal cancers expressing GPR120. Anticancer agent 316 can be used in the research of colorectal cancer.
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- No. CAS: 337495-81-5
- Fòrmula: C31H28N2O2S
- Peso molecular:492.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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GPR120 |
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Cell Line
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Type | Value | Description | References |
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| SW480 | IC50 |
23.21 μM
Compound: 1
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Anticancer activity against human SW480 cells expressing GPR120 assessed as inhibition of cell viability measured after 24 hrs by alamar blue assay
Anticancer activity against human SW480 cells expressing GPR120 assessed as inhibition of cell viability measured after 24 hrs by alamar blue assay
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[PMID: 33161126] |
Anticancer agent 316 (0.39-100 µM; 24-72 h) potently inhibits the growth of colorectal cancer cell line SW480, with a 24-hour IC50 of 23.21-26.69 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW480 human colorectal cancer (CRC) cells expressing GPR120
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Concentration:1 µM (72 h); 10 µM (72 h); 100 µM (72 h); 0.39-100 µM (24 h, 48 h, 72 h)
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Incubation Time:24 h; 48 h; 72 h
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Result:Showed ~90% inhibitory effects on SW480 cell growth at 100 µM for 72 hours.
Exhibited an IC50 of 23.21-26.69 µM after 24-hour treatment.
Increased IC50 to ~50-60 µM after 48 hours.
Chemical Information
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No. CAS 337495-81-5
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Peso molecular 492.63
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Fòrmula C31H28N2O2S
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SMILES
O=C1C2=C(C3=C(CC24CCCC4)C=CC=C3)N=C(N1C5=CC=C(C)C=C5)SCC(C6=CC=CC=C6)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 316 Related Classifications
HY-182404 Related Classifications
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