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Referencia número: HY-119731

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Antidesmone

Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum. Antidesmone can prevent acute lung injury in vivo via inhibiting MAPK and NF-κb activities.

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No. CAS: 222629-77-8
Fòrmula: C₁₉H₂₉NO₃
Peso molecular:319.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antidesmone Chemical Structure

No. CAS: 222629-77-8

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Actividad biológica
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- Cellular Effect
Chemical Information
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Bioz

Actividad biológica

Descripciòn

Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum^[1]. Antidesmone can prevent acute lung injury in vivo via inhibiting MAPK and NF-κb activities^[2].

Ver todos los productos específicos de isoformas p38 MAPK :

Ver todos los productos específicos de isoformas NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.4 μM Compound: 8	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
HeLa	IC₅₀	23.4 μg/mL Compound: 13	Cytotoxicity against human HeLa cells after 48 hrs by SRB assay Cytotoxicity against human HeLa cells after 48 hrs by SRB assay	[PMID: 26848627]
KB	IC₅₀	17.7 μM Compound: 8	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
L6	IC₅₀	184.3 μM Compound: 10	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25314007]
MCF7	IC₅₀	6.4 μM Compound: 8	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MDA-MB-231	IC₅₀	6.7 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
RAW264.7	IC₅₀	16.1 μM Compound: 18	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS stimulation and measured after 20 hrs by Griess reagent based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS stimulation and measured after 20 hrs by Griess reagent based assay	[PMID: 36746775]

Chemical Information

No. CAS 222629-77-8
Peso molecular 319.44
Fòrmula C₁₉H₂₉NO₃
SMILES

O=C1C(OC)=C(C)NC2=C1[C@@H](CCCCCCCC)CCC2=O
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lu X, et al. Antidesmone, a unique tetrahydroquinoline alkaloid, prevents acute lung injury via regulating MAPK and NF-κB activities. Int Immunopharmacol. 2017 Apr;45:34-42. [Content Brief]

[2]. Buske, et al. Antidesmone, a novel type isoquinoline alkaloid from Antidesma membranaceum (Euphorbiaceae). Tetrahedron, 55(4), 1079–1086.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Antidesmone

Ver todos los productos específicos de isoformas p38 MAPK

Ver todos los productos específicos de isoformas NF-κB

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Antidesmone Related Classifications

HY-119731 Related Classifications