APG-7
APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC50 of 24.2 μg/mL). APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C30H26O12
- Peso molecular:578.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
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TLR4 |
APG-7 (25 μg/mL) inhibits the formation of superoxide anion with 29.06% inhibition[1].
APG-7 (0.1-100 μg/mL; 48 h) showed no toxicity at ∼25 μg/mL on fibroblast cells[1].
In-silico anti-cancer activity analysis reveals that APG-7 displays anti-cancer activity for B-lymphoblastic cells, colon adenocarcinoma, non-small cell lung carcinoma, and metastatic melanoma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3 fibroblast cells
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Concentration:100 μg/mL, 10 μg/mL, 1.0 μg/mL, 0.1 μg/mL
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Incubation Time:48 h
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Result:Moderately suppressed the production of free radicals. Did not show toxicity up to concentration of 25 μg/mL.
Chemical Information
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Peso molecular 578.52
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Fòrmula C30H26O12
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SMILES
O[C@@H]1[C@@H](OC2=CC=C(C=C2)C3=CC(C4=C(C=C(C=C4O3)O)O)=O)O[C@@H](COC(/C=C/C5=CC=C(C=C5)O)=O)[C@H](O)[C@@H]1O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APG-7 Related Classifications
HY-179036 Related Classifications
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