Apoptosis inducer 50
Apoptosis inducer 50 (Compound 5e) is an apoptosis inducer as well as an autophagy inducer agent. Apoptosis inducer 50 exhibits potent and selective anti-cancer activity against triple-negative breast cancer cells and metastatic colon cancer cells. Apoptosis inducer 50 upregulates the expression of pro-apoptotic proteins (Bax, Bim, cleaved Caspase-9) and downregulates the expression of the anti-apoptotic protein (BCL-XL). Apoptosis inducer 50 upregulates key autophagy markers such as Beclin-1 and ATG5, and enhances the conversion of LC3-I to LC3-II., Apoptosis inducer 50 arrests cancer cells in the G1/S phase by upregulating the expression of p21 and p27 while downregulating Cyclin D1. Apoptosis inducer 50 increases the level of ROS.
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- Fòrmula: C34H24N8O6
- Peso molecular:640.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Bax |
Bim |
Caspase-9 |
Bcl-xL |
CDK1 |
Chemical Information
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Peso molecular 640.60
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Fòrmula C34H24N8O6
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SMILES
OC1=CC=CC=C1C2=NC(C3=CC=CC=C3O)=NN2C4=CC=C(C(N/N=C/C5=CC(/N=N/C6=CC=C([N+]([O-])=O)C=C6)=CC=C5O)=O)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 50 Related Classifications
HY-179052 Related Classifications
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