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Referencia número: HY-103265A

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ARL67156

(Synonyms: FPL 67156)

3 Cited Publications

Revisión del cliente

Based on 3 publication(s) in Google Scholar

ARL67156 is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12 μM, respectively.

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No. CAS: 160928-38-1
Fòrmula: C₁₅H₂₄Br₂N₅O₁₂P₃
Peso molecular:719.11

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

ARL67156 Chemical Structure

No. CAS: 160928-38-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

ARL67156 is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12 μM, respectively^[1].

IC₅₀ & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)^[1]

In Vitro

ARL67156 is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 160928-38-1
Peso molecular 719.11
Fòrmula C₁₅H₂₄Br₂N₅O₁₂P₃
SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(C(Br)(Br)P(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N(CC)CC)=NC=N3)N=C2
Synonyms

FPL 67156
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Neuron

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. [Abstract]

2022 Mar 2;110(5):770-782.e5. PMID: 34942116
Front Immunol

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation. [Abstract]

2022 Oct 4:13:946871. PMID: 36268017
Curr Eye Res

Integrated Spatiotemporal and Correlative Analysis of ATP-Related Signaling Components in Lens Development. [Abstract]

2026 Apr;51(4):359-373. PMID: 41310968

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lévesque SA, et al. Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases. Br J Pharmacol. 2007 Sep;152(1):141-50. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ARL67156

3 Cited Publications

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ARL67156

Publications Citing Use of MedChemExpress (MCE) ARL67156

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Publications (3)

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ARL67156 Related Classifications

HY-103265A Related Classifications