ArMan
ArMan is a co-activator of DC-SIGN (CD209) and TLR7. ArMan can selectively bind to DC-SIGN, promoting receptor-mediated endocytosis of the virus-like particle (VLP) platform, thereby enhancing co-binding with TLR7. ArMan can drive dendritic cell activation, shifting the immune response from humoral immunity to type 1 cellular immunity. ArMan can be used in melanoma research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C19H25NO7
- Peso molecular:379.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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TLR7 |
ArMan (8 nM; 30 min) displayed by VLPs exhibits enhanced colocalization with DC-SIGN and TLR7 in human monocyte-derived dendritic cells following 30 min of incubation[1].
ArMan (8 nM; 24 h) displayed by VLPs induces robust activation of human monocyte-derived dendritic cells, with significantly increased surface expression of CD40, CD80, CD83, and CD86 after 24 h of incubation, dependent on DC-SIGN binding[1].
ArMan (8 nM; 6 h) displayed by VLPs upregulate TLR7-associated gene expression and hallmark DC activation pathways in human monocyte-derived dendritic cells after 6 h of incubation[1].
ArMan (8 nM; 32 h) displayed by VLPs induce significantly higher secretion of pro-inflammatory cytokines (TNF-α, IL-6, CXCL10, IL-8, IL-12p70) by human monocyte-derived dendritic cells after 32 h of incubation, dependent on DC-SIGN engagement[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ArMan (s.c. or i.p.; days 3, 9, 15) delivered via VLPs functions as a self-adjuvanting cancer vaccine component, inducing robust tumor antigen-specific CD8+ T cell responses and supporting anti-tumor efficacy in mice without the need for additional adjuvants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 379.40
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Fòrmula C19H25NO7
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SMILES
OC[C@H]([C@H]([C@@H]1O)O)O[C@@H]([C@H]1O)OC2=CC=C(CCNC(CCC#C)=O)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ArMan Related Classifications
HY-175421 Related Classifications
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