Ascr#10
Ascr#10 (Asc-C9) is an orally active thermogenesis inducer and insecticide that can be obtained from Monochamus alternatus. Ascr#10 binds to the insect adipokinetic hormone (AKH) receptor (Ka=272 µM) and stimulates mitochondrial biogenesis via the PGC1α-UCP4 axis. Consequently, Ascr#10 induces UCP4-mediated uncoupled respiration, reduces the ATP/ADP ratio and accelerates lipid mobilization, thereby driving the thermogenesis process. Ascr#10 delays pupation and exerts specific chemotaxis toward dispersive fourth-stage pinewood nematode LIV larvae. Ascr#10 promotes cold acclimation of Monochamus alternatus larvae through metabolic inhibition and cryoprotectant accumulation, enhancing their survival rate under cold stress. Ascr#10 also induces browning of white adipose tissue and activates brown adipose tissue in mice, thereby helping the body resist cold and tumor growth. Ascr#10 can be widely applied to research related to pine wilt disease, lung tumors and cold stress.
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- No. CAS: 1355681-08-1
- Fòrmula: C15H28O6
- Peso molecular:304.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Ascr#10 (300 nM) activates AKHR in transfected Drosophila S2 cells, triggering a greater than 60% maximum increase in intracellular Ca2+ fluorescence intensity[2].
Ascr#10 (3 aM-3 µM; 72 h) increases fecundity of native Bursaphelenchus xylophilus isolate US1 at concentrations of 3 aM, 3 fM, and 3 pM after 72 h incubation[4].
Ascr#10 (0.1 nM; 10 days) drives gene expression changes linked to metabolic depression and accumulation of cryoprotectants like glycerol, trehalose, and sorbitol in last-instar larval Monochamus alternatus[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ascr#10 (10 mg/kg; i.p. injection; every 2 days; 4 weeks) activates BAT and induces subcutaneous WAT browning in mice to enhance thermogenesis and cold tolerance, while also inhibiting lung tumor growth[2].
Ascr#10 (0.1 nM; mixed into artificial diet; continuous feeding; 10 days) enhances cold hardiness in 5th instar Monochamus alternatus larvae, reducing LT50 by 3.2 °C via metabolic depression and upregulation of cryoprotectant synthesis genes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5th (final) instar larvae of Japanese pine sawyer beetle[5]
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Dosage:0.1 nM
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Administration:mixed into artificial diet; continuous feeding; 10 days
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Result:Markedly decreased supercooling points from day 4 of treatment.
Reduced lethal temperature causing 50% mortality (LT50) to -15.4 °C, which was 3.2 °C lower than control.
Identified 1601 differentially expressed transcripts, with 78 of 100 genes in the "metabolic process" GO term downregulated.
Significantly upregulated genes encoding enzymes for cryoprotectant synthesis (trehalose-phosphate phosphatase, glycogen phosphorylase, aldose-1-epimerase, aldo-keto reductase, glucose-6-phosphate isomerase).
Significantly downregulated enolase (a TCA cycle enzyme).
Chemical Information
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No. CAS 1355681-08-1
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Peso molecular 304.38
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Fòrmula C15H28O6
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SMILES
O([C@@H](CCCCCCC(O)=O)C)[C@H]1[C@H](O)C[C@@H](O)[C@H](C)O1
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Synonyms
Asc-C9
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Zhao L, et al. Ascarosides coordinate the dispersal of a plant-parasitic nematode with the metamorphosis of its vector beetle. Nat Commun. 2016;7:12341. Published 2016 Aug 1. [Content Brief]
[3]. Zhou J, et al. A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor. Adv Sci (Weinh). 2026;13(10):e09822. [Content Brief]
[4]. Zhao M, et al. Major ascaroside pheromone component asc-C5 influences reproductive plasticity among isolates of the invasive species pinewood nematode. Integr Zool. 2021;16(6):893-907. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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