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Referencia número: HY-161573

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BAY-593

Revisión del cliente

Based on 1 Customer Validation

BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.94%
No. CAS: 2413020-56-9
Fòrmula: C₂₆H₃₁F₃N₂O₃
Peso molecular:476.53

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BAY-593 Chemical Structure

No. CAS: 2413020-56-9

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Precio

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Amount: USD 0.00

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity^[1].

IC₅₀ & Target

GGTase I

Ver todos los productos específicos de isoformas YAP :

Ver todos los productos específicos de isoformas GGTase :

GGTase I

In Vitro

BAY-593 (0.5 nM-10 μM; 72 h) inhibits the proliferation of HT-1080 and MDA-MB-231 cells with the IC₅₀ values of 0.038 and 0.564 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BAY-593 (2.5-20 mg/kg; oral administration; 14 days) shows dose-dependent antitumor activity in HT-1080 fibrosarcoma and MDA-MB-231 triple negative breast cancer xenotransplantation mouse models^[1].
Pharmacokinetic Analysis in HT-1080 xenograft mouse models^[1]

Route	Dose (mg/kg)	Schedule	T/C_volume on day 9	C_max (μg/L)	4 days AUC (mg·h/L)	4 days AUC_unbound (μg·h/L)
p.o.	2.5	BID	0.44	100	2.6	37
p.o.	5	QD	0.43	76	2.8	39
p.o.	10	Q2D	0.069	350	5.4	76
p.o.	20	Q4D	0.063	2262	16.0	224
p.o.	5	BID	0.056	275	8.0	112
p.o.	10	QD	0.021	321	14.0	196

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2413020-56-9
Appearance Solid
Peso molecular 476.53
Fòrmula C₂₆H₃₁F₃N₂O₃
Color White to off-white
SMILES

O=C(N1CCC2(CCNC[C@@]2([H])C3=CC=CC=C3OC)CC1)[C@@](OC)(C(F)(F)F)C4=CC=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 116.67 mg/mL (244.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0985 mL

10.4925 mL

20.9850 mL

5 mM

0.4197 mL

2.0985 mL

4.1970 mL

10 mM

0.2099 mL

1.0493 mL

2.0985 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Graham K, et al. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0985 mL	10.4925 mL	20.9850 mL	52.4626 mL
	5 mM	0.4197 mL	2.0985 mL	4.1970 mL	10.4925 mL
	10 mM	0.2099 mL	1.0493 mL	2.0985 mL	5.2463 mL
	15 mM	0.1399 mL	0.6995 mL	1.3990 mL	3.4975 mL
	20 mM	0.1049 mL	0.5246 mL	1.0493 mL	2.6231 mL
	25 mM	0.0839 mL	0.4197 mL	0.8394 mL	2.0985 mL
	30 mM	0.0700 mL	0.3498 mL	0.6995 mL	1.7488 mL
	40 mM	0.0525 mL	0.2623 mL	0.5246 mL	1.3116 mL
	50 mM	0.0420 mL	0.2099 mL	0.4197 mL	1.0493 mL
	60 mM	0.0350 mL	0.1749 mL	0.3498 mL	0.8744 mL
	80 mM	0.0262 mL	0.1312 mL	0.2623 mL	0.6558 mL
	100 mM	0.0210 mL	0.1049 mL	0.2099 mL	0.5246 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
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BAY-593

MCE Bioactive Compound Library

Ver todos los productos específicos de isoformas YAP

Ver todos los productos específicos de isoformas GGTase

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

BAY-593 Related Classifications

HY-161573 Related Classifications