Bibenzyl
Based on 1 Customer Validation
Bibenzyl (s-Diphenylethane; Dibenzyl) is the parent core structure of bibenzyl-type natural products and an intermediate in organic synthesis. Hydroxyl-substituted derivatives of Bibenzyl are mainly isolated from plants such as Dendrobium (Orchidaceae) and Cannabaceae. These derivatives accumulate when plants are exposed to fungal infection and biotic stress, and exhibit antioxidant, anti-inflammatory, and anti-hepatic steatosis activities.
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- Pureza : 99.97%
- No. CAS: 103-29-7
- Fòrmula: C14H14
- Peso molecular:182.26
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-W008814
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4-tert-ButyltolueneDrug Intermediate -
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1-EthylnaphthaleneBiochemical Reagent -
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tert-PentylbenzeneFungal Metabolite -
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9,10-Dihydrophenanthrene9,10-Phenanthrenequinone Analogue
Actividad biológica
Descripciòn
In Vitro
Bibenzyl derivatives (such as bibenzyl-dihydrophenanthrene derivatives from Dendrobium parishii) dose-dependently reduce H2O2-induced ROS levels in RAW264.7 macrophages, enhance the activities of SOD, GPx and CAT, and inhibit LPS-induced iNOS and COX-2 expression at concentrations of 12.5-50 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 103-29-7
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Appearance Solid
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Peso molecular 182.26
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Fòrmula C14H14
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Color White to off-white
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SMILES
C1(CCC2=CC=CC=C2)=CC=CC=C1
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Synonyms
s-Diphenylethane; Dibenzyl
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (548.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[2]. Zhang ZM, et al. Bibenzyl and naphthalene derivatives from Dendrobium chrysanthum and their anti-hepatic-steatosis activities. Bioorganic chemistry. 2024 Apr;145:107236. [Content Brief]
[3]. Boddington KF, et al. Bibenzyl synthesis in Cannabis sativa L. Plant J. 2022 Feb;109(3):693-707. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.4867 mL | 27.4333 mL | 54.8667 mL | 137.1667 mL |
| 5 mM | 1.0973 mL | 5.4867 mL | 10.9733 mL | 27.4333 mL | |
| 10 mM | 0.5487 mL | 2.7433 mL | 5.4867 mL | 13.7167 mL | |
| 15 mM | 0.3658 mL | 1.8289 mL | 3.6578 mL | 9.1444 mL | |
| 20 mM | 0.2743 mL | 1.3717 mL | 2.7433 mL | 6.8583 mL | |
| 25 mM | 0.2195 mL | 1.0973 mL | 2.1947 mL | 5.4867 mL | |
| 30 mM | 0.1829 mL | 0.9144 mL | 1.8289 mL | 4.5722 mL | |
| 40 mM | 0.1372 mL | 0.6858 mL | 1.3717 mL | 3.4292 mL | |
| 50 mM | 0.1097 mL | 0.5487 mL | 1.0973 mL | 2.7433 mL | |
| 60 mM | 0.0914 mL | 0.4572 mL | 0.9144 mL | 2.2861 mL | |
| 80 mM | 0.0686 mL | 0.3429 mL | 0.6858 mL | 1.7146 mL | |
| 100 mM | 0.0549 mL | 0.2743 mL | 0.5487 mL | 1.3717 mL |
Bibenzyl Related Classifications
HY-78004 Related Classifications
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