CAY10580
Based on 1 Customer Validation
CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.4%
- No. CAS: 64054-40-6
- Fòrmula: C19H35NO4
- Peso molecular:341.49
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Almacenamiento:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
EP4 35 nM (Ki) |
EP2 3000 nM (Ki) |
EP3 2000 nM (Ki) |
EP1 >3000 nM (Ki) |
In Vitro
CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3]
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Dosage:200 μg/kg body weight
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Administration:Intraperitoneal injection; daily for remaining three weeks
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Result:High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
Chemical Information
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No. CAS 64054-40-6
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Appearance Liquid
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Peso molecular 341.49
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Fòrmula C19H35NO4
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Color Colorless to light yellow
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SMILES
O=C(O)CCCCCCN1C(CCC(O)CCCCC)CCC1=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Billot X, et al. Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Med Chem Lett. 2003;13(6):1129-1132. [Content Brief]
[2]. Olesen ET, et al. Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2011;108(31):12949-12954. [Content Brief]
[3]. Ying F, et al. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(9):1029-1040. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAY10580 Related Classifications
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