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Referencia número: HY-128061

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CDIBA

CDIBA is a cytosolic phospholipase A2 (cPLA2) inhibitor. CDIBA inhibits the activation of cPLA2 in rat diaphragm tissue. CDIBA reduces the level of mitochondrial reactive oxygen species in rat diaphragm tissue after prolonged mechanical ventilation. CDIBA attenuates protein degradation, muscle atrophy and decreased muscle strength in the diaphragm of rats after prolonged mechanical ventilation. CDIBA can be used in studies related to ventilator-induced diaphragmatic dysfunction.

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No. CAS: 479422-22-5
Fòrmula: C₃₁H₂₆ClNO₃
Peso molecular:496.00

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDIBA Chemical Structure

No. CAS: 479422-22-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Phospholipase :

Cellular Effect

Cell Line	Type	Value	Description	References
MC9	Inhibition	-8 % Compound: 25	Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM	[PMID: 16392799]
MC9	Inhibition	81 % Compound: 25	Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM	[PMID: 16392799]
MC9	Inhibition	96 % Compound: 25	Inhibition of LTB4 production in MC9 cells at 1.5 uM Inhibition of LTB4 production in MC9 cells at 1.5 uM	[PMID: 16392799]

In Vivo

CDIBA (30 mg/kg; i.p.; single injection at ventilation onset; 5 mg/kg/h; i.v.; continuous infusion; 12 hours) attenuates ventilator-induced diaphragm dysfunction in rats by reducing cPLA2 activation, mitochondrial ROS production, calpain activity, muscle atrophy, and improving diaphragm contractile force^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult male, SPF level, 450-550 g, ventilator-induced diaphragm dysfunction model)^[1]
Dosage:

30 mg/kg (i.p. injection); 5 mg/kg/h (continuous i.v. infusion)
Administration:

i.p. (single injection at ventilation onset); i.v. (continuous infusion; 12 hours)
Result:

Significantly reduced cPLA2 activation in the diaphragm.
Decreased mitochondrial H₂O₂ production in the diaphragm.
Downregulated diaphragm calpain activity.
Reduced the expression of atrophy-related genes Atrogin-1 and MuRF-1 in the diaphragm.
Increased the cross-sectional area of slow-twitch and fast-twitch diaphragm muscle fibers.
Improved diaphragm contractile function, including increased maximal tetanic forces, elevated force-frequency curve responses, and enhanced fatigue tolerance, compared to untreated ventilated rats.

Chemical Information

No. CAS 479422-22-5
Peso molecular 496.00
Fòrmula C₃₁H₂₆ClNO₃
SMILES

O=C(O)C1=CC=C(OCCC=2C=3C=C(Cl)C=CC3N(C2C)C(C=4C=CC=CC4)C=5C=CC=CC5)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhou XL, et al. Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction. Oxid Med Cell Longev. 2019;2019:2561929. Published 2019 Apr 18. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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