CGP-75355
CGP-75355 is an inhibitor of HIV-1 protease with IC50 of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 191594-64-6
- Fòrmula: C39H53N5O7
- Peso molecular:703.87
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT2 | ED50 |
0.7 nM
Compound: 25a
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Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells.
Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells.
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[PMID: 9719591] |
| MT2 | IC50 |
58 nM
Compound: 25a
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The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.
The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.
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[PMID: 9719591] |
Chemical Information
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No. CAS 191594-64-6
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Peso molecular 703.87
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Fòrmula C39H53N5O7
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SMILES
CC(C)(C)[C@@H](C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C3=CC=CC=C3)C=C2)=O)NC(OC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Bold, G., et al., (1998). New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development. Journal of medicinal chemistry, 41(18), 3387-3401. [Content Brief]
[2]. Wieslaw M. Kazmierski, (2011). Antiviral Drugs: From Basic Discovery Through Clinical Trials.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGP-75355 Related Classifications
HY-117559 Related Classifications
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