Chitobiose
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 577-76-4
- Fòrmula: C12H24N2O9
- Peso molecular:340.33
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Chitobiose (100 μM; 24 h prior to LPS stimulation) exhibits no anti-inflammatory activity in LPS (HY-D1056)-stimulated RAW264.7 cells, as it does not alter levels of IL-1β, IL-10, IL-17A, or IFN-γ[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RAW264.7 macrophage cells
-
Concentration:100 μM
-
Incubation Time:24 h (prior to 6 h LPS stimulation)
-
Result:Showed no significant effect on the levels of IL-1β, IL-10, IL-17A, and IFN-γ compared to the control group (p > 0.05).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:CCl4-induced acute hepatotoxicity Wistar (male, 7 weeks old, 165-185 g)[2]
-
Dosage:300 mg/kg
-
Administration:p.o.; twice (30 minutes before and 3 hours after CCl4 exposure)
-
Result:Significantly suppressed the CCl4-induced increase in the sum of malondialdehyde and 4-hydroxy-2-alkenals in both plasma and liver at 24 hours post-CCl4 treatment.
Significantly reduced the elevated plasma aspartate transaminase (AST) and alanine transaminase (ALT) activities at both 6 hours and 24 hours post-CCl4 treatment.
Chemical Information
-
No. CAS 577-76-4
-
Peso molecular 340.33
-
Fòrmula C12H24N2O9
-
SMILES
N[C@H]([C@H]([C@@H]([C@@H](CO)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1N)O)O)CO)O)C=O
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020;2020:2394704. Published 2020 Apr 11. [Content Brief]
[2]. Chen AS, et al. Effect of chitobiose and chitotriose on carbon tetrachloride-induced acute hepatotoxicity in rats. Biol Pharm Bull. 2005;28(10):1971-1973. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chitobiose Related Classifications
HY-N7697F Related Classifications
Powered by Bioz