CN045
CN045 is a blood-brain barrier-permeable, selective M1 muscarinic receptor ligand with an IC50 value of 1 μM. CN045 enhances remyelination in mouse brain regions. CN045 can be used in studies related to multiple sclerosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 401809-27-6
- Fòrmula: C16H22Cl3NO2
- Peso molecular:366.71
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
mAChR1 1 μM (IC50) |
In Vitro
CN045 (5 days) potently stimulates differentiation of primary mouse OPCs into mature, myelin protein-expressing oligodendrocytes with an EC50 of 0.04 μM[2].
CN045 (1 μM; 14 days) promotes myelin-like ensheathment of engineered nanofibers by primary mouse OPCs, increasing both oligodendrocyte numbers and ensheathment length[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57/BL/6J (8-week-old male; multiple sclerosis model via 12 weeks of 0.3% cuprizone chow plus daily i.p. sirolimus 10 mg/kg-induced demyelination)[2]
-
Dosage:10 mg/kg
-
Administration:i.p.; daily; 6 weeks
-
Result:Increased remyelination in the corpus callosum, hippocampus, and cerebral cortex compared to vehicle treatment.
Increased the number of PPD+ myelinated axons per unit area in the corpus callosum.
Increased the percentage area of PLP staining in the hippocampus.
Increased the percentage area of PLP staining in the cerebral cortex.
Chemical Information
-
No. CAS 401809-27-6
-
Peso molecular 366.71
-
Fòrmula C16H22Cl3NO2
-
SMILES
ClC1=C(OCCOCCN2CCC(C)CC2)C(Cl)=CC(Cl)=C1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CN045 Related Classifications
HY-187683 Related Classifications
Powered by Bioz